PMID: 8945091Nov 1, 1996Paper

Role of Na(+)-H+ exchange on reperfusion related myocardial injury and arrhythmias in an open-chest swine model

Pacing and Clinical Electrophysiology : PACE
M FukutaT Kobayashi

Abstract

The inhibition of Na(+)-H+ exchange (NHE) with amiloride analogues in vitro has been shown to prevent reperfusion arrhythmias and additional cell necrosis. Inhibition of intracellular Ca2+ overload via NHE inhibition has been suggested as a mechanism of these protective effects. The aim of this study was to examine whether treatment with amiloride analogues reduces the incidence of reperfusion arrhythmias and limits infarct size in vivo. Open-chest swine were exposed to a 30-minute left anterior descending artery (LAD) occlusion and 180 minutes of reperfusion during atrial pacing at 150 ppm. Intravenous 5-(N,N-dimethyl)-amiloride (AML, 5 micrograms/kg per min) was administered in the treatment group (n = 7) and intravenous saline in the control group (n = 7), starting 10 minutes before coronary occlusion. The infusion was continued during ischemia and reperfusion. The area at risk was defined by monastral blue dye and infarct size by triphenyltetrazolium chloride staining. Limb leads ECG and monophasic action potentials (MAPs) from the epicardium in the ischemic area were recorded. There was no significant difference in the size of the area at risk and hemodynamic parameters between the groups. However, the infarcted area was 0...Continue Reading

References

Apr 1, 1992·Journal of Cardiovascular Pharmacology·J Duan, M P Moffat
May 1, 1991·Circulation Research·E MurphyC Steenbergen
Nov 1, 1981·Japanese Circulation Journal·Y KobayashiT Katagiri
Sep 8, 1993·JAMA : the Journal of the American Medical Association·W D WeaverM Eisenberg
Feb 17, 1993·Molecular and Cellular Biochemistry·T IshibashiS Imai

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Citations

Jun 8, 2001·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M D CarcelesM L Laorden
Jan 11, 2001·Journal of Pharmacological and Toxicological Methods·S C Black
Feb 16, 2002·The Annals of Thoracic Surgery·Steven P GoldbergWilliam L Holman
Nov 9, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Joseph PyeTimothy C Nichols

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