Role of natural interferon-producing cells and T lymphocytes in porcine monocyte-derived dendritic cell maturation.

Immunology
Laurence Guzylack-PiriouArtur Summerfield

Abstract

Maturation of dendritic cells (DC) is a key immunological process regulating immune responses to pathogens and vaccines, as well as tolerance and autoimmune processes. Consequently, the regulation of DC maturation should reflect these multifaceted immunological processes. In the present study, we have defined the role of particular cytokines, Toll-like receptor (TLR) ligands and T lymphocytes in the porcine monocyte-derived DC (MoDC). Interferon-alpha (IFN-alpha) alone was a poor inducer of MoDC maturation, but in association with tumour necrosis factor-alpha (TNF-alpha), or TLR ligands such as lipopolysaccharide and polyinosinic-polycytidylic acid I:C, an up-regulation of major histocompatibility complex II and CD80/86 expression was noted, along with reduced endocytic activity. In contrast, TNF-alpha alone or in combination with the TLR ligands was a poor inducer of DC maturation, but co-operated with T-lymphocytes in the presence of antigen to induce DC maturation. Natural interferon producing cells (NIPC, or plasmacytoid DCs) represent a danger-recognition system of the immune defences, and can respond to viruses not otherwise recognized as posing a danger. Indeed, MoDC did not respond to transmissible gastroenteritis virus...Continue Reading

References

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Citations

Jul 15, 2011·Clinical and Vaccine Immunology : CVI·Eva SonckEric Cox
Jul 5, 2013·Journal of Virology·Jazmina L G CruzSonia Zúñiga
Dec 18, 2009·Developmental and Comparative Immunology·Laurence Guzylack-PiriouArtur Summerfield
Dec 22, 2009·Veterinary Immunology and Immunopathology·Bert DevriendtEric Cox
Sep 6, 2008·Developmental and Comparative Immunology·Kenneth C McCullough, Artur Summerfield
Jun 28, 2008·Developmental and Comparative Immunology·Artur Summerfield, Kenneth C McCullough
Sep 15, 2009·Reviews in Medical Virology·Gerlinde R Van de WalleHerman W Favoreel
Sep 19, 2006·Veterinary Immunology and Immunopathology·Agnès JaminGaëlle Kuntz-Simon
Nov 28, 2008·Veterinary Immunology and Immunopathology·Kenneth C McCulloughArtur Summerfield
Nov 12, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gael AurayArtur Summerfield
Jan 14, 2017·Frontiers in Immunology·Cindy Bernelin-CottetIsabelle Schwartz-Cornil

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Methods Mentioned

BETA
flow cytometry
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

SigmaPlot
SigmaStat
Flowjo

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