Role of neoadjuvant chemoradiotherapy in clinical T2N0M0 esophageal cancer: A population-based cohort study

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Lucas GoenseRichard van Hillegersberg

Abstract

The aim of this population-based cohort study was to determine whether the addition of neoadjuvant chemoradiotherapy (nCRT) to surgery is associated with improved pathologic outcomes and survival in patients with cT2N0M0 esophageal cancer. Patients who underwent nCRT followed by surgery or surgery alone for cT2N0M0 esophageal cancer were identified from The Netherlands Cancer Registry database (2005-2014). Accuracy of clinical staging was assessed using the resection specimen as gold standard. After propensity score matching, influences of both treatment strategies on radical resection (R0) rates and overall survival were compared. In total 533 patients were included; 353 underwent nCRT followed by surgery and 180 underwent surgery alone. In the nCRT group 32% of patients achieved a pathologic complete response. Clinical understaging was observed in 62% of the patients in the surgery alone group based on pT-stage (n = 30, 27%), pN-stage (n = 26, 23%), or both (n = 55, 50%). Propensity score matching resulted in 78 patients who underwent nCRT plus surgery versus 78 who underwent surgery alone. In the nCRT group radical resections were more frequently observed (99% vs. 89% p = 0.031) and resulted in improved 5-year overall surviv...Continue Reading

Citations

Jul 19, 2020·The Annals of Thoracic Surgery·Kristen E RhodinThomas A D'Amico
Feb 23, 2021·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Paul WolfsonSarmed S Sami
Jan 2, 2019·The Journal of Thoracic and Cardiovascular Surgery·Matthew Fox
Jun 19, 2021·Annals of Surgical Oncology·Giovanni CapovillaMichele Valmasoni
Jan 24, 2021·The Annals of Thoracic Surgery·Wilson Luiz da CostaNader N Massarweh
Dec 19, 2019·Annals of Surgery·Siva RajaUNKNOWN Worldwide Esophageal Cancer Collaboration Investigators

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