PMID: 2499891Jun 1, 1989Paper

Role of neuromedin B in the control of the release of thyrotropin in the rat

Proceedings of the National Academy of Sciences of the United States of America
V RettoriS M McCann

Abstract

Neuromedin B (NB), a bombesin-like peptide, was first isolated from porcine spinal cord and subsequently found in the central nervous systems of rat, cat, and human. Immunocytochemical studies have shown that NB is present in hypothalamus and various other regions of the brain and in thyrotrophs of the anterior pituitary of the rat. The possible physiological role of NB in the hypothalamic-pituitary axis is not known. Therefore, we studied the in vivo effect of this peptide on the plasma levels of thyrotropin (TSH) after administering NB to conscious freely moving adult male rats. When injected i.v., only the highest dose of NB (50 micrograms, 44.2 nmol) significantly lowered plasma TSH levels relative to levels in saline controls. When injected intraventricularly, NB doses of 0.5 and 5 micrograms (0.44 and 4.42 nmol, respectively) lowered plasma TSH levels with a 15-min latency period. Responsiveness of the pituitary to TSH-releasing hormone (TRH) was tested after the effective dose of NB was administered i.v. The increase in plasma TSH levels after the i.v. injection of 1 microgram of TRH was not altered by NB. NB at 10(-9) to 10(-7) M also reduced TSH release from hemipituitaries incubated in vitro without decreasing the res...Continue Reading

Citations

Jan 1, 1994·Peptides·H Houben, C Denef
Dec 6, 2000·European Journal of Pharmacology·T W MoodyJ Leyton
Aug 12, 2003·European Journal of Pharmacology·Terry W MoodyRobert T Jensen
Dec 21, 2002·Life Sciences·Rachel Moraes MoreiraCarmen C Pazos-Moura
Jun 7, 2000·Progress in Neurobiology·H Ohki-Hamazaki
Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·V RettoriS M McCann
Oct 3, 2000·Thyroid : Official Journal of the American Thyroid Association·F H CurtyC C Pazos-Moura
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