Role of neuropeptides in sex pheromone production in moths

Peptides
M Altstein

Abstract

Sex pheromone biosynthesis in many moth species is controlled by a cerebral neuropeptide, termed pheromone biosynthesis activating neuropeptide (PBAN). PBAN is a 33 amino acid C-terminally amidated neuropeptide that is produced by neuroendocrine cells of the subesophageal ganglion (SEG). Studies of the regulation of sex pheromone biosynthesis in moths have revealed that this function can be elicited by additional neuropeptides all of which share the common C-terminal pentapeptide FXPRL-amide (X = S, T, G, V). In the past two decades extensive studies were carried out on the chemical, cellular and molecular aspects of PBAN and the other peptides (termed the pyrokinin (PK)/PBAN family) aiming to understand the mode of their action on sex pheromone biosynthesis. In the present review we focus on a few of these aspects, specifically on the: (i) structure-activity relationship (SAR) of the PK/PBAN family, (ii) characterization of the PK/PBAN receptor and (iii) development of a novel strategy for the generation of PK/PBAN antagonists and their employment in studying the mode of action of the PK/PBAN peptides.

References

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Citations

Mar 1, 2011·FEBS Letters·Luca SchiesariRodolfo Costa
May 1, 2012·General and Comparative Endocrinology·Paweł MarciniakGrzegorz Rosiński
Sep 3, 2009·Peptides·Elisabeth MarchalJozef Vanden Broeck
May 26, 2009·Peptides·Aliza HaritonMiriam Altstein
May 26, 2009·Peptides·Aliza HaritonMiriam Altstein
Nov 6, 2008·General and Comparative Endocrinology·Suparna Taneja-BageshwarRonald J Nachman
Dec 10, 2008·Peptides·Ronald J NachmanMiriam Altstein
Dec 7, 2007·Frontiers in Neuroendocrinology·Frank HauserCornelis J P Grimmelikhuijzen
Aug 2, 2005·Biochemical and Biophysical Research Communications·Giuseppe CazzamaliCornelis J P Grimmelikhuijzen
Oct 27, 2006·Journal of Neurophysiology·Shari R SaidemanMichael P Nusbaum
Sep 13, 2005·The Journal of Experimental Biology·Nina Wedell
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Krzysztof KaczmarekRonald J Nachman

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