Role of neuropsin in formation and maturation of Schaffer-collateral L1cam-immunoreactive synaptic boutons

Journal of Cell Science
Yukiko NakamuraSadao Shiosaka

Abstract

We report that neuropsin is involved in the synaptogenesis/maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway. Most non-synaptic orphan boutons and a number of immature small synaptic boutons expressed the cell adhesion molecule L1 in presynaptic Schaffer-collateral terminals, whereas mature large boutons on mushroom spines were devoid of L1. The number of L1-immunoreactive boutons was markedly higher in neuropsin-deficient mice than in wild-type mice, whereas there were far fewer mature large boutons. L1-immunoreactive boutons were hypertrophied in the mutant mice. When a recombinant active neuropsin was microinjected into the mutant hippocampus, the number of immunoreactive synaptic boutons reverted to wild-type levels after one day. These results strongly suggest that enzymatically active neuropsin allows a maturational change of L1-immunoreactive small boutons, both orphan and synaptic, and this step may be important in synaptic plasticity based on activity-dependent structural change.

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Citations

Mar 1, 2012·Cell and Tissue Research·Michael K E Schäfer, Michael Frotscher
Mar 21, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Aiko IzumiHiroshi Kunugi
Mar 15, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tomoko YamadaAzad Bonni
Jun 28, 2014·Trends in Neurosciences·Peter Sonderegger, Kazumasa Matsumoto-Miyai
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Feb 24, 2015·Nature Reviews. Drug Discovery·Ioannis PrassasEleftherios P Diamandis
Oct 12, 2012·Cell Biochemistry and Function·Shoko Morita, Seiji Miyata
Sep 4, 2019·Translational Psychiatry·A StarnawskaL Christiansen
Jun 5, 2013·Reviews in the Neurosciences·Hideki TamuraSadao Shiosaka
May 18, 2020·The Journal of Physiological Sciences : JPS·Lina BukowskiPer Qvist

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