Role of new biomarkers for predicting renal scarring in vesicoureteral reflux: NGAL, KIM-1, and L-FABP

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Gönül ParmaksızNurcan Cengiz

Abstract

Reflux nephropathy is the most serious complication of vesicoureteral reflux (VUR). The aim of this study was to assess the role of urinary levels of neutrophil-gelatinase-associated lipocalin (NGAL),kidney injury molecule-1 (KIM-1), and liver-type fatty-acid-binding protein (L-FABP) in the early diagnosis of reflux nephropathy in patients with VUR. This study assessed 123 patients with primary VUR and 30 healthy children as a control group. The children were divided into five groups: Group A, patients with VUR and renal parenchymal scarring (RPS); Group B, patients with VUR and without RPS; Group C, patients with RPS and resolved VUR; Group D, patients with resolved VUR and without RPS; Group E, healthy reference group. Median urinary NGAL (uNGAL)/Creatinine (Cr) was significantly higher in patients with than those without RPS and the control group (p = 0.0001). Median uKIM-1/Cr was similar in all groups (p = 0.417). Median uL-FABP/Cr was significantly higher in patients with RPS than in the reference group (p < 0.05). Urinary NGAL levels may be used as a noninvasive diagnostic marker for predicting renal scarring in reflux nephropathy.

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Citations

Aug 24, 2016·International Urology and Nephrology·Meryem BenzerAslı Uluturk Tekin
Oct 28, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Catherine S Forster, Prasad Devarajan
Dec 14, 2019·International Urology and Nephrology·Olga MorozovaIvan Budnik
Aug 6, 2020·International Journal of Molecular Sciences·Satoshi WashinoTomoaki Miyagawa
Jun 15, 2017·Investigative and Clinical Urology·Michaella Maloney Prasad, Earl Y Cheng
Dec 12, 2019·International Urology and Nephrology·Azar NickavarMostafa Moosavian
Mar 14, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Catherine S ForsterStuart L Goldstein
Feb 18, 2017·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Catherine S ForsterRichard S Lee
Jan 7, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Aleksandra Stankovic
Jan 8, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Sohsaku YamanouchiKazunari Kaneko
Jun 3, 2021·Journal of Clinical Medicine·Joanna Bagińska, Agata Korzeniecka-Kozerska

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