Role of NF-κB/IKK-dependent signaling in functional stimulation of mesenchymal progenitor cells by alkaloid songorine

Bulletin of Experimental Biology and Medicine
G N Zyuz'kovA M Dygai

Abstract

We studied the role of NF-κB/IKK-mediated signaling in the stimulation of growth potential of mesenchymal progenitor cells by alkaloid songorine in vitro. Specific NF-κB inhibitor oridonin abolished activation of proliferation and differentiation of progenitor cells. Aurothiomalate, a selective blocker of IKK-2, also suppressed mitotic activity of fibroblast precursors, but had no effect on the rate of the differentiation.

References

Jan 21, 2003·Bulletin of Experimental Biology and Medicine·G N Zyuz'kovE D Gol'dberg
Jun 9, 2006·Bulletin of Experimental Biology and Medicine·G N Zyuz'kovE D Gol'dberg
Jan 25, 2008·Bulletin of Experimental Biology and Medicine·G N Zyuz'kovE D Goldberg
Jan 25, 2008·Bulletin of Experimental Biology and Medicine·E D GoldbergL A Gur'yantseva
Oct 17, 2008·Bulletin of Experimental Biology and Medicine·G N Zyuz'kovE D Gol'dberg
Nov 1, 2012·Bulletin of Experimental Biology and Medicine·G N Zyuz'kovA M Dygai
Mar 14, 2013·Bulletin of Experimental Biology and Medicine·A M DygaiV I Agafonov
Oct 19, 2013·Bulletin of Experimental Biology and Medicine·G N Zyuz'kovA M Dygai
Nov 30, 2013·Bulletin of Experimental Biology and Medicine·G N Zyuz'kovA M Dygai
Dec 10, 2013·Bulletin of Experimental Biology and Medicine·G N Zyuz'kovA M Dygai
Apr 29, 2014·Bulletin of Experimental Biology and Medicine·Yu V NesterovaA V Krapivin

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