Role of nitric oxide and beta-adrenoceptors of the central nervous system on the salivary flow induced by pilocarpine injection into the lateral ventricle

Pharmacology, Biochemistry, and Behavior
W A SaadSylvio Simões

Abstract

Our studies have focused on the effect of L-NG-nitroarginine methyl ester (L-NAME), an inhibitor of nitric oxide synthase (NOS), and L-arginine, the substrate of NOS, on salivary secretion induced by the administration of pilocarpine into the lateral cerebral ventricle (LV) of rats. The present study has also investigated the role of the beta-adrenergic agonists and antagonist injected into LV on the salivary secretion elicited by the injection of pilocarpine into LV. Male Holtzman rats with a stainless-steel cannula implanted into the LV were used. The amount of salivary secretion was studied over a 7-min period after injection of pilocarpine, isoproterenol, propranolol, salbutamol, salmeterol, L-NAME and L-arginine. The injection of pilocarpine (10, 20, 40, 80 and 160 microg/microl) into LV produced a dose-dependent increase in salivary secretion. The injection of L-NAME (40 microg/microl) into LV alone produced an increase in salivary secretion. The injection of L-NAME into LV previous to the injection of pilocarpine produced an increase in salivary secretion. L-Arginine (30 microg/microl) injected alone into LV produced no change in salivary secretion. L-Arginine injected into LV attenuated pilocarpine-induced salivary secr...Continue Reading

References

Sep 1, 1978·Physiology & Behavior·T SchallertJ J Braun
Oct 1, 1992·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·Y Iwabuchi, T Masuhara
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Jul 1, 1967·The Journal of Physiology·N Emmelin, J Holmberg
Mar 1, 1994·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·J Damas
Feb 1, 1994·Comparative Biochemistry and Physiology. Pharmacology, Toxicology and Endocrinology·Y IwabuchiT Masuhara
Feb 1, 1993·Oral Surgery, Oral Medicine, and Oral Pathology·M M Ferguson
Sep 8, 1998·Neuroimmunomodulation·A LomnicziS M McCann
Apr 2, 1999·European Journal of Oral Sciences·D Stojic
Nov 24, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·W A SaadS Simões

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.