Role of nitric oxide and carbon monoxide in N(omega)-Nitro-L-arginine methyl ester-resistant acetylcholine-induced relaxation in chicken carotid artery

European Journal of Pharmacology
Marie Dennis Marcus LeoSantosh K Mishra

Abstract

The current study examined the hypothesis that acetylcholine-induced N(omega)-Nitro-L-arginine methyl ester (L-NAME)-resistant endothelium-dependent relaxations in the chicken carotid artery are mediated by nitric oxide and carbon monoxide. Acetylcholine (1 nM-3 microM) caused a concentration-dependent relaxation (pD(2) 6.81+/-0.05, R(max) 115+/-3%) of the artery segments precontracted with phenylephrine (3 microM). L-NAME (1 mM) decreased the sensitivity (pD(2) 6.44+/-0.06), but not the efficacy (R(max) 108+/-3%) of acetylcholine. It also partially decreased the acetylcholine (3 microM)-stimulated nitrite release. While treatment with N(omega)-Nitro-L-arginine (l-NNA; 1 mM) plus L-NAME (1 mM) decreased the acetylcholine-stimulated nitrite release to the basal level, it moderately inhibited (R(max) 77+/-3%) the maximal relaxation elicited with the muscarinic agonist. 2-Phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide (PTIO; 100 microM) a specific scavenger of nitric oxide (NO) plus the two NOS inhibitors further decreased the acetylcholine-evoked relaxation (R(max) 34+/-2%). Although soluble guanylyl cyclase (sGC) inhibitor 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ; 10 microM) markedly inhibited the acetylcholine-sti...Continue Reading

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Citations

May 4, 2013·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Catherine JarrettKaren L Sweazea
Dec 17, 2014·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·John A DonaldMelissa S Cameron
Oct 9, 2014·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Marie Dennis LeoDinesh Kumar
Aug 21, 2016·Cell and Tissue Research·Melissa S CameronJohn A Donald
Aug 5, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Saskia van der SterrenEduardo Villamor
Aug 2, 2013·The Journal of Pharmacology and Experimental Therapeutics·Muhammad Oneeb Rehman MianErnesto L Schiffrin
Jun 27, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Melissa S Cameron, John A Donald

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