Role of nitric oxide and vascular endothelial growth factor in fluoride-induced goitrogenesis in rats

Environmental Toxicology and Pharmacology
Guoyan LiuChunyan Chai

Abstract

Endemic fluorosis is a serious problem in public health. Previous studies have indicated that patients with thyroid goiters usually live in fluoride-affected areas. However, the mechanism of goitrogenesis caused independently by fluoride is still unclear. The principle objective of this study was to investigate the possible roles of nitric oxide (NO) and vascular endothelial growth factor (VEGF) in the genesis of fluoride-induced nodular goiters. Eighty SD rats (40 males and 40 females) at the age of 4 weeks were used to establish animal models via fluoride-supplemented drinking water. These rats were randomly divided into four groups of 20. Group 1 was used as the control and were given deionized water. Group 2 (LF), group 3 (MF), and group 4 (HF) were given deionized water containing 50mg/L, 100mg/L, and 200mg/L of sodium fluoride (NaF), respectively. Thyroid samples were collected on day 150. Pathological observation was performed to evaluate structural changes in the thyroid gland. The expression of VEGF mRNA in the thyroid glands was assessed by reverse transcriptional PCR. The serum NO level was analyzed by spectrometric methods. In addition, immunohistochemistry was conducted to evaluate expression and deposition of VEGF...Continue Reading

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Citations

Sep 21, 2013·Toxicology Letters·Ekambaram PerumalLakshmikanthan Panneerselvam
Aug 12, 2014·Environmental Toxicology and Pharmacology·Hongliang LiuAiguo Wang
Mar 8, 2013·Environmental Toxicology and Pharmacology·Wenpeng WangHuabing Li
Sep 1, 2015·Biological Trace Element Research·Yaqiu JiangWeiping Teng
Sep 22, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Jian-Tao JiangSheng Chen
Jul 28, 2016·Dental Materials : Official Publication of the Academy of Dental Materials·Jie LiuFarida Fortune

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