Abstract
Endemic fluorosis is a serious problem in public health. Previous studies have indicated that patients with thyroid goiters usually live in fluoride-affected areas. However, the mechanism of goitrogenesis caused independently by fluoride is still unclear. The principle objective of this study was to investigate the possible roles of nitric oxide (NO) and vascular endothelial growth factor (VEGF) in the genesis of fluoride-induced nodular goiters. Eighty SD rats (40 males and 40 females) at the age of 4 weeks were used to establish animal models via fluoride-supplemented drinking water. These rats were randomly divided into four groups of 20. Group 1 was used as the control and were given deionized water. Group 2 (LF), group 3 (MF), and group 4 (HF) were given deionized water containing 50mg/L, 100mg/L, and 200mg/L of sodium fluoride (NaF), respectively. Thyroid samples were collected on day 150. Pathological observation was performed to evaluate structural changes in the thyroid gland. The expression of VEGF mRNA in the thyroid glands was assessed by reverse transcriptional PCR. The serum NO level was analyzed by spectrometric methods. In addition, immunohistochemistry was conducted to evaluate expression and deposition of VEGF...Continue Reading
References
Feb 1, 1992·Endocrine Reviews·N FerraraD W Leung
May 1, 1989·The Journal of Experimental Medicine·D J Stuehr, C F Nathan
Dec 1, 1995·Endocrinology·I M ColinJ L Jameson
Jun 6, 1998·The Journal of Endocrinology·J F WangD J Hill
Aug 24, 1999·The Journal of Biological Chemistry·H HeR B Caldwell
Sep 24, 1999·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·N Ferrara
Oct 13, 2000·The Journal of Endocrinology·J D Ramsden
Nov 26, 2002·Cardiovascular Research·Józef Dulak, Alicja Józkowicz
Mar 11, 2003·Antioxidants & Redox Signaling·Józef Dulak, Alicja Józkowicz
Jun 5, 2003·Nature Medicine·Peter Carmeliet
Jun 28, 2003·Pathology International·Wonsick ChoeSeung Sook Lee
Dec 25, 2003·Journal of Hazardous Materials· MeenakshiAnju Malik
Sep 15, 2004·Life Sciences·Józef DulakAlicja Józkowicz
Sep 7, 2006·Endocrine-related Cancer·N Garcia de la TorreH E Turner
Jul 24, 2010·Chemico-biological Interactions·Olivier BarbierLuz María Del Razo
Citations
Sep 21, 2013·Toxicology Letters·Ekambaram PerumalLakshmikanthan Panneerselvam
Aug 12, 2014·Environmental Toxicology and Pharmacology·Hongliang LiuAiguo Wang
Mar 8, 2013·Environmental Toxicology and Pharmacology·Wenpeng WangHuabing Li
Sep 1, 2015·Biological Trace Element Research·Yaqiu JiangWeiping Teng
Sep 22, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Jian-Tao JiangSheng Chen
Nov 16, 2013·Toxicology Letters·Hongliang LiuAiguo Wang
Jul 28, 2016·Dental Materials : Official Publication of the Academy of Dental Materials·Jie LiuFarida Fortune
Mar 2, 2016·Biomedical Materials·Zeinab Tahmasebi BirganiPamela Habibovic
Jul 22, 2017·Biological Trace Element Research·Yao TengJuan Feng
Jan 23, 2021·Biological Trace Element Research·Yuhui DuYue Ba