Role of nitric oxide in a nonseptic shock model induced by zymosan in the rat

Shock
S CuzzocreaF Rossi

Abstract

Nitric oxide (NO) is a short-lived mediator, the synthesis of which is induced by various cytokines during inflammatory processes. Recently, it has been proposed that zymosan, a nonbacterial agent, causes inflammation by inducing the production of various cytokines and proinflammatory mediators. In the present study we investigated the role of NO in a nonseptic shock model induced by zymosan administration in the rat. Administration of zymosan (500 mg/kg, intraperitoneally) in the rat induced acute peritonitis, as assessed by a marked increase in the leukocytes count in the exudate, as well as by an increase in the exudate nitrate/nitrite concentration. Zymosan-treated rats developed a severe hypotension and showed signs of systemic illness, significant loss of body weight, and a high mortality rate (53% of animals died within 72 h). Elevated plasma levels of nitrite and nitrate were also observed in zymosan-treated rats compared with control rats (67 +/- 4 microM and 23 +/- 2 microM, respectively; p < .01). In ex vivo experiments, vascular reactivity was studied in thoracic aorta rings of zymosan-treated rats. The contractile responses to norepinephrine (100 nM) and endothelin-1 (5 nM) were significantly reduced. An impairment...Continue Reading

Citations

Jan 7, 1999·European Journal of Pharmacology·G CostantinoA P Caputi
Jul 31, 2003·Pharmacology & Therapeutics·Ian A Clark, William B Cowden
Jan 6, 1999·Critical Care Medicine·C LuongoF Rossi
Feb 24, 2001·Critical Care Medicine·D E TaylorB deBoisblanc
Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·D T Efron, A Barbul
Feb 18, 2006·Critical Care Medicine·Salvatore CuzzocreaChristoph Thiemermann
Sep 19, 2006·Shock·Rosanna Di PaolaSalvatore Cuzzocrea
Dec 4, 2008·Critical Care Medicine·Rosanna Di PaolaSalvatore Cuzzocrea
May 7, 2008·Pharmacology, Biochemistry, and Behavior·Masataka Saito, Shiro Watanabe
Jul 9, 2004·Life Sciences·Stefania MarzoccoGiuseppina Autore
Oct 24, 2002·Critical Care Medicine·Salvatore CuzzocreaChristoph Thiemermann
Mar 15, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Michael C MontaltoGregory L Stahl
Feb 14, 2019·BMC Complementary and Alternative Medicine·Tamires Rocha FalcãoGerlane Coelho Bernardo Guerra

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