PMID: 7541879Jul 1, 1995Paper

Role of nitric oxide in human esophageal circular smooth muscle in vitro

The Journal of Thoracic and Cardiovascular Surgery
W G RichardsD J Sugarbaker

Abstract

The role of nitric oxide in human esophageal smooth muscle was examined. Immunostaining for constitutive nitric oxide synthase labeled nerve fibers and bundles within longitudinal and circular smooth muscle layers of resected tissue samples. Strips of circular muscle mounted in organ baths exhibited spontaneous contractions and active tone. When exposed to 5-second trains of electric field stimulation at 20 Hz, most strips exhibited intrastimulus "on" and poststimulus "off" contractions. Exposure to a 0.1 mumol/L (or greater) concentration of atropine converted "on" contractions to "on" relaxations and reduced "off" contractions by 63%. Exposure to NG-nitro-L-arginine resulted in concentration-dependent enhancement of "on" contractions and abolition of "off" contractions. Excess L-arginine enhanced the reversal of these effects. Sodium nitroprusside inhibited both spontaneous and evoked contractions. These results suggest that nitric oxide synthesis is a mediator of neural inhibition of human esophageal circular smooth muscle and is necessary for the occurrence of "off" contractions.

Citations

Apr 1, 1994·Digestive Diseases and Sciences·H G PreiksaitisN E Diamant
Sep 12, 2000·Current Gastroenterology Reports·H Park, J L Conklin
Sep 6, 2012·British Journal of Pharmacology·G J SangerC H Knowles
Jul 25, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J BroadG J Sanger
Feb 6, 1998·The Journal of Laboratory and Clinical Medicine·J L Conklin
Jul 11, 1998·Journal of Pediatric Surgery·J A TovarJ Arana
Mar 16, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Asensio A GonzálezPere Clavé
Apr 28, 2009·American Journal of Respiratory and Critical Care Medicine·Loretta G QueMonica Kraft
Apr 1, 1996·Pflügers Archiv : European journal of physiology·G V Petkov, K K Boev
May 21, 2011·American Journal of Respiratory and Critical Care Medicine·Nadzeya V Marozkina, Benjamin Gaston
Aug 20, 2005·Pharmacological Reviews·Noboru Toda, Arnold G Herman

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