Role of nitric oxide in hyporeactivity to noradrenaline of isolated aortic rings in portal hypertensive rats

European Journal of Pharmacology
P P MichielsenP A Pelckmans

Abstract

To test the hypothesis that induction of nitric oxide synthase causes systemic vascular hyporesponsiveness to vasopressors in portal hypertension, we performed in vitro experiments on isolated thoracic aortic rings from partial portal vein ligated or sham operated rats at 3 weeks postoperatively. The concentration-response curves to noradrenaline of intact and endothelium-denuded aortic rings from portal hypertensive rats were significantly shifted to the right as compared to those from sham operated animals. Maximal contractions did not significantly differ. Addition of NG-nitro-L-arginine, a specific inhibitor of nitric oxide synthase, shifted the curves to the left in both sham operated and portal hypertensive rats, so that in intact rings, the concentrations of noradrenaline producing half-maximal response did not significantly differ any more between sham operated and portal vein ligated rats. In endothelium-denuded rings, a hyporeactivity to noradrenaline persisted in portal vein ligated rats. Furthermore, NG-nitro-L-arginine induced an additional significant increase in the maximal response to noradrenaline in sham operated as compared to portal hypertensive rats. The endothelium-dependent relaxations to acetylcholine we...Continue Reading

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Sep 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A HeinemannR E Stauber
Jan 1, 1997·Pharmacology & Therapeutics·P W Hadoke, P C Hayes
Feb 1, 1997·Journal of Hepatology·V SafkaD Lebrec
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Jun 11, 2005·Journal of Gastroenterology and Hepatology·René RobertChristine Silvain
Jun 15, 2007·Journal of Gastroenterology and Hepatology·Moattar Raza RizviShiv Kumar Sarin
Apr 23, 2004·Liver International : Official Journal of the International Association for the Study of the Liver·Isabelle ColleMartine DeVos
Sep 1, 1995·Journal of Hepatology·P A Cahill, J V Sitzmann
Aug 17, 2001·European Journal of Gastroenterology & Hepatology·T C SchmandraE W Hanisch
Sep 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P P MichielsenP A Pelckmans
May 20, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Isabelle ColleHans Van Vlierberghe
Apr 13, 2004·European Journal of Gastroenterology & Hepatology·Isabelle O ColleMartine M De Vos
Dec 4, 2014·World Journal of Gastroenterology : WJG·Qing-Hong DuXu Jia

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