Role of nitric oxide in regulation of cerebral microvascular tone and autoregulation of cerebral blood flow in cats

Brain Research
M KobariH Takeda

Abstract

The role of nitric oxide in the regulation of cerebrocortical microvascular tone and autoregulation of cerebral blood flow (CBF) was examined in 24 anesthetized cats. The local cerebral blood volume (CBV), mean transit time of blood (MTT), and CBF in the cortex were measured by our photoelectric method. CBV represents the cumulative dimensions of the cerebral microvessels. Intravenous injection of 0.35-0.7 mg/kg/min NG-monomethyl-L-arginine (L-NMMA), an inhibitor of nitric oxide synthesis, significantly increased mean arterial blood pressure (MABP; 8.4-14.1%, P < 0.01), decreased CBV (15.2-28.7%, P < 0.01), and decreased CBF (20.0-29.8%, P < 0.01) in a dose-related manner. The changes in MABP, CBV, and CBF elicited by L-NMMA were inhibited (P < 0.05) by simultaneous infusion of 35 mg/kg/min L-arginine. Autoregulation of CBF was examined during controlled hypotension of -30 to -40 mmHg (artificial bleeding) and recovery of blood pressure (reinfusion of blood). Although CBF remained constant with blood pressure changes in the control state (delta CBF/delta MABP of 0.037 +/- 0.155 with hypotension), CBF became dependent on blood pressure changes (delta CBF/delta MABP of 0.478 +/- 0.135, P < 0.05) during infusion of 0.35 mg/kg/min ...Continue Reading

References

Feb 8, 2003·Experimental Eye Research·Anton ReinerMalinda E C Fitzgerald
Feb 22, 2011·Journal of Neurotrauma·Claudia S RobertsonJ Clay Goodman
Nov 5, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K ToyodaM Fujishima
Jun 19, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·M IngyinnM Viswanathan
Feb 11, 2000·Annals of the New York Academy of Sciences·C C Chiueh
May 21, 2011·The Journal of Pediatrics·Anthony J OconJulian M Stewart
Sep 2, 2014·Psychophysiology·Ben AllenStephen B Manuck
May 30, 1998·The Journal of Thoracic and Cardiovascular Surgery·L C WagerleD A Davis
Mar 19, 2002·The Journal of Physiology·Thomas MüllerMatthias Schwab
Jun 2, 2005·Pathophysiology : the Official Journal of the International Society for Pathophysiology·William M Armstead
Sep 16, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Stephen C JonesAlejandro D Perez-Trepichio
Aug 27, 1999·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·S HarinoP Reinach
May 23, 2014·Frontiers in Neuroscience·Clare Howarth
May 30, 2003·Pharmacological Reviews·Noboru Toda, Tomio Okamura
Jan 31, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Zoltán BenyóPál Pacher
Sep 21, 2007·American Journal of Physiology. Cell Physiology·Jessica A FilosaLaura V Gonzalez Bosc
Mar 19, 2009·Pharmacological Reviews·Noboru TodaTomio Okamura
Oct 15, 2010·International Journal of Immunopathology and Pharmacology·S Delli PizziA Tartaro
Aug 21, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Rehan T JunejoJames P Fisher
Jan 25, 2000·Journal of Biomedical Science·T J Lee

Citations

Oct 1, 1992·Stroke; a Journal of Cerebral Circulation·W I Rosenblum
Mar 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E KoźniewskaT Styś
May 15, 1991·Biochemical and Biophysical Research Communications·M A DwyerS H Snyder
Jul 16, 1990·Biochemical and Biophysical Research Communications·K S WoodL J Ignarro
Oct 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M TomitaI Gerdsen
Mar 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C IadecolaN A Lassen
Jan 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K NozakiS H Snyder
Nov 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·I M MacraeJ McCulloch
Jan 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M KobariH Takeda
Jan 1, 1993·Brain Research Bulletin·M KobariS Matsuoka

Related Concepts

Arginine hydrochloride
Cerebral Blood Flow Imaging
Nitric Oxide Biosynthetic Process
Omega-N-Methylarginine
Cortex Bone Disorders
Adrenal Cortex Diseases
Blood Flow Velocity
Intravenous Injections
Diastolic Blood Pressure
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