Role of Nitric Oxide in the Development of Cataract Formation in CdCl2-induced Hypertensive Animals

Current Eye Research
Apurva YadavSurendra Haribhau Bodakhe

Abstract

Previously we established a strong association of systemic hypertension with cataract formation. In the present study, we investigated the role of nitric oxide (NO) in the development of cataract formation in CdCl2-induced hypertensive animals. Hypertension was induced in male albino rats by intraperitoneal administration of CdCl2 (0.5 mg/kg/day) for eight weeks. The NO modulators, 10 µM S-nitrosoglutathione (NO donor) and 1% w/v Nω-nitro-L-arginine methyl ester (L-NAME, NOS inhibitor) were applied topically once a day on the eye cornea during the experimental period. Amlodipine (3mg/kg/day) was used as a standard antihypertensive drug and administered orally. In the CdCl2 control group, mean arterial pressure was significantly increased along with augmentation of lens nitrite, opacity, and oxidative stress. The control of hypertension by amlodipine substantially restored lens nitrite and cataractogenic events. Moreover, topical application of L-NAME significantly alleviated the lens nitrite, opacity, antioxidants (GSH, CAT, SOD, and GPx), MDA, proteins, and ionic (Na+ and Ca2+) contents. Whereas, S-nitrosoglutathione topical application exacerbated these cataractogenic events without affecting hypertension as compared to CdCl2...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Jan 1, 1978·Methods in Enzymology·A L Tappel
Jan 1, 1989·Pharmacology·R BalaramanK G Hemavathi
Feb 1, 1987·Current Eye Research·T R ShearerR S Anderson
Jun 1, 1972·Analytical Biochemistry·A K Sinha
Oct 1, 1982·Analytical Biochemistry·L C GreenS R Tannenbaum
Jun 11, 1998·Human Reproduction Update·M RosselliR K Dubey
Jan 25, 2000·Experimental Eye Research·D C Paik, J Dillon
Oct 24, 2000·Biochimica Et Biophysica Acta·T WeiA Mori
Feb 13, 2001·Annals of Epidemiology·D A SchaumbergC H Hennekens
Apr 28, 2001·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·G C Chiou
Jul 20, 2001·Current Eye Research·Y ItoM Tomohiro
Feb 5, 2003·Experimental Eye Research·Tomohiro NabekuraYoshimasa Ito
Feb 19, 2003·Experimental Eye Research·Kemal OrnekZeliha Büyükbingöl
May 1, 1959·Archives of Biochemistry and Biophysics·G L ELLMAN
Jan 22, 2004·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Stefania GiuffridaFilippo Drago
Jul 29, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G E EriyamremuV E Osagie
Nov 26, 2009·Free Radical Biology & Medicine·Ramar ManikandanMunuswamy Arumugam
Jan 21, 2010·Physiological Reviews·Richard T MathiasXiaohua Gong
Jul 17, 2010·Journal of Ophthalmology·Andreas Pollreisz, Ursula Schmidt-Erfurth
Sep 24, 2010·Drug News & Perspectives·Filippo Drago, Claudio Bucolo
Mar 16, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R Michael, A J Bron
Dec 3, 2011·The British Journal of Ophthalmology·Donatella Pascolini, Silvio Paolo Mariotti
May 25, 2013·Cardiovascular Toxicology·Chukwuemeka R NwokochaPaul D Brown
Sep 17, 2013·Journal of Cellular Physiology·Mohammad ShahidullahNicholas A Delamere
Apr 5, 2014·Investigative Ophthalmology & Visual Science·Mariana A B RosalesJacqueline M Lopes de Faria
Dec 5, 2014·PloS One·Xiaoning YuKe Yao
Sep 1, 2016·Journal of Current Ophthalmology·Samsroz Ahmad KhanSurendra H Bodakhe
Oct 12, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Rajesh Choudhary, Surendra H Bodakhe
Oct 13, 2016·Therapeutics and Clinical Risk Management·Rehab M El-GharabawyAmal H Al-Najjar

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Citations

Apr 9, 2019·Journal of Biochemical and Molecular Toxicology·Jaya ShreeSurendra H Bodakhe
Apr 14, 2021·Journal of Biochemical and Molecular Toxicology·Rajesh ChoudharySurendra H Bodakhe

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