Role of nitric oxide in the elevation of cerebral blood flow induced by acetylcholine and anoxia in the turtle

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
P HyllandP L Lutz

Abstract

Nitric oxide (NO)-dependent regulation of brain blood flow has hitherto not been studied in reptiles. By observing the brain surface (telencephalon) of the freshwater turtle (Trachemys scripta) with epiillumination microscopy, we show that topical application of acetylcholine (ACh) induces an increase in CBF velocity that can be completely blocked by the NO synthase inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME). The effect of L-NAME was reversed by L-arginine. Also, sodium nitroprusside (SNP), which decomposes to liberate NO, caused an increase in CBF velocity. By contrast, L-NAME could not block the increase in blood flow velocity caused by anoxia. Interestingly, superfusing the brain with ACh or SNP during anoxia had no effect on the blood flow velocity. The results suggest that NO is an endogenous vasodilator in the turtle brain, mediating the effects of ACh during normoxia. By contrast, anoxia does not rely on NO as a vasodilator.

References

Mar 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E KoźniewskaT Styś
Mar 1, 1992·Biofeedback and Self-regulation·N E Miller
Nov 1, 1990·British Journal of Pharmacology·D D ReesS Moncada
Jan 1, 1988·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·R Bissoli, A Contestabile
Jan 1, 1988·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·T AkasuT Tokimasa
Jan 1, 1986·Blood Vessels·V M Miller, P M Vanhoutte
May 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P Hylland, G E Nilsson
Nov 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·I M MacraeJ McCulloch
Nov 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Y Morita-TsuzukiE Bouskela
Sep 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P HyllandP L Lutz
Aug 1, 1994·The American Journal of Physiology·N M Shanbaky, T A Pressley
Mar 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F ZhangC Iadecola
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D W Choi
Jan 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D A PelligrinoR F Albrecht
May 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T MalinskiM Chopp
Sep 1, 1995·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·W Hanke, W Kloas

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Citations

Feb 24, 2005·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Gina L J GalliTobias Wang
Mar 20, 1998·Comparative Biochemistry and Physiology. Part A, Physiology·G E Nilsson, V Söderström
Jul 10, 1999·Neuroscience Letters·V SöderströmC E Franklin
Dec 17, 2014·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·John A DonaldMelissa S Cameron
Jun 19, 2008·Physiology & Behavior·Aline R G GuerraKênia C Bícego
Jul 3, 2007·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Narihiro YoshinagaAtsushi Miyamoto
Jun 29, 2005·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Nini SkovgaardTobias Wang
Aug 18, 2016·Frontiers in Physiology·Anna BogdanovaAntonio Martínez-Ruiz
Jun 18, 2016·Journal of Neurochemistry·Ying Wang, B Jill Venton
Jan 22, 2005·Journal of Experimental Zoology. Part A, Comparative Experimental Biology·Kai E SwensonErik R Swenson
Feb 19, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sarah L Milton, Peter L Lutz
Feb 19, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jonathan A W StecykTobias Wang
Apr 18, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sarah L MiltonPeter L Lutz
Mar 3, 2015·Physiology·Angela Fago, Frank B Jensen
May 10, 2007·The Journal of Experimental Biology·Johannes OvergaardTobias Wang
May 13, 1999·Biochimica Et Biophysica Acta·J P Bolaños, A Almeida
Oct 20, 2006·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Sarah L Milton, Howard M Prentice

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Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
P Hylland, G E Nilsson
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
P HyllandP L Lutz
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