PMID: 8614276Jan 1, 1996Paper

Role of nitric oxide in the maintenance of resting cerebral blood flow during chronic hypertension

Life Sciences
S T Yang

Abstract

The influence of nitric oxide (NO) on basal vascular tone varies with different hypertensive models or vascular beds. The goal of the present study was to examine the role of NO in the maintenance of resting cerebral blood flow (CBF) during chronic hypertension. In 9-10 months old Wistar-Kyoto (WKY) rats (n=47) and spontaneously hypertensive rats (SHR;n=47) anesthetized with pentobarbital sodium (60 mg/kg i.p.), regional CBF of the right parietal cortex was monitored by laser-Doppler flowmetry. Reductions in CBF in response to intravenous infusion of the NO synthase inhibitor N(omega)-nitro-L-arginine methyl ester (L-NAME; 1, 3, 10, and 30 mg/kg) were similar between WKY rats (17 +/- 6 approximately 43 +/- 6%; means +/- SE) and SHR (15 +/- 6 approximately 48 +/- 6%) while arterial blood pressure was maintained on the baseline level by controlled hemorrhage. Effects of L-NAME (3 mg/kg i.v.) on arterial blood pressure and CBF were almost completely inhibited by L-arginine (300 mg/kg i.v.), but not by D-arginine (300 mg/kg i.v.). In addition, intravenous infusion of L-arginine (300 mg/kg) alone did not affect resting CBF in both WKY rats and SHR. Thus, these findings suggest that 1) NO plays an important role in the maintenance of...Continue Reading

References

Sep 16, 1992·Biochemical and Biophysical Research Communications·D A PetersonE K Weir
Dec 1, 1992·Acta Physiologica Scandinavica·Y Morita-TsuzukiJ E Hardebo
Mar 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E KoźniewskaT Styś
May 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F M Faraci, D D Heistad

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Citations

May 1, 1997·British Journal of Pharmacology·I P FouyasI R Whittle
May 30, 2003·Pharmacological Reviews·Noboru Toda, Tomio Okamura
Nov 15, 2001·Journal of Cardiovascular Pharmacology·L M TsaiJ M Yang
Dec 17, 2009·Molecular and Cellular Biochemistry·N V PerriconeHarry G Preuss
Feb 11, 1998·Physiological Reviews·F M Faraci, D D Heistad
Feb 28, 2002·Journal of Cardiovascular Pharmacology·Ana M BrionesMercedes Salaices
Nov 15, 1997·The American Journal of Physiology·W J PearceS Ashwal
Jun 12, 1998·Japanese Journal of Pharmacology·N Toda, T Okamura

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