PMID: 7528917Sep 1, 1994Paper

Role of nitric oxide in the pancreatic blood flow response to caerulein

Pancreas
A SatohT Toyota

Abstract

To clarify the role of nitric oxide (NO) in the pancreas, blood flow in the rat pancreas (pancreatic blood flow: PBF) was investigated by the hydrogen clearance technique using a specific NO synthase inhibitor, N omega-nitro-L-arginine (L-NNA). Continuous infusion of caerulein at doses of 5 and 20 micrograms/kg/h caused a significant increase in PBF in the early phase of caerulein infusion. The caerulein-induced increase in PBF was not affected significantly by atropine sulfate (100 micrograms/kg), nor by phenoxybenzamine (5 mg/kg) plus propranolol (50 micrograms/kg). Administration of L-NNA (0.5, 5, or 30 mg/kg) did not affect the basal PBF, but at 5 mg/kg it inhibited completely the caerulein-induced increase in PBF. The inhibitory action of L-NNA was reversed by a large dose of L-arginine (100 mg/kg bolus, i.v., followed by a continuous infusion at 400 mg/kg/h), but not by its enantiomer D-arginine. These results strongly suggest that NO has a mediator role in the early phase vascular response of the pancreas to superphysiologic doses of caerulein.

Citations

Jul 23, 2011·Antioxidants & Redox Signaling·Péter Hegyi, Zoltán Rakonczay
Jul 6, 2010·European Journal of Pharmacology·Amany A AbdinMohammed F H Balaha
Dec 6, 2005·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Thomas GriesbacherDiana Groisman
Oct 1, 2008·Acta Cirúrgica Brasileira·Roberto Ferreira MeirellesPaulo Roberto Barbosa Evora
Jan 1, 1996·Scandinavian Journal of Gastroenterology. Supplement·J H Sweiry, G E Mann
Mar 30, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Sebastian PratschkeMartin Kurt Angele
Jan 13, 2000·International Journal of Experimental Pathology·A Andrzejewska, G Jurkowska

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