Role of nitric oxide in the pathogenesis of Barrett's-associated carcinogenesis

World Journal of Gastrointestinal Pathophysiology
Gen KusakaTooru Shimosegawa

Abstract

Barrett's esophagus (BE), a premalignant condition to Barrett's adenocarcinoma (BAC), is closely associated with chronic inflammation due to gastro-esophageal reflux. Caudal type homeobox 2 (CDX2), a representative marker of BE, is increased during the metaplastic and neoplastic transformation of BE. Nitric oxide (NO) has been proposed to be a crucial mediator of Barrett's carcinogenesis. We previously demonstrated that CDX2 might be induced directly under stimulation of large amounts of NO generated around the gastro-esophageal junction (GEJ) by activating epithelial growth factor receptor in a ligand-independent manner. Thus, we reviewed recent developments on the role of NO in Barrett's carcinogenesis. Notably, recent studies have reported that microbial communities in the distal esophagus are significantly different among groups with a normal esophagus, reflux esophagitis, BE or BAC, despite there being no difference in the bacterial quantity. Considering that microorganism components can be one of the major sources of large amounts of NO, these studies suggest that the bacterial composition in the distal esophagus might play an important role in regulating NO production during the carcinogenic process. Controlling an infla...Continue Reading

References

Apr 7, 1994·Nature·N BenjaminH McKenzie
Oct 21, 2000·Gastroenterology·D G SilbergP G Traber
Feb 13, 2001·The Journal of Clinical Investigation·Y Yamamoto, R B Gaynor
Apr 19, 2002·JAMA : the Journal of the American Medical Association·Nicholas Shaheen, David F Ransohoff
Apr 19, 2002·JAMA : the Journal of the American Medical Association·Nicholas Shaheen, David F Ransohoff
Nov 16, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sara CalatayudMaría Dolores Barrachina
Mar 5, 2003·Free Radical Biology & Medicine·Ananth S PannalaCatherine A Rice-Evans
Apr 16, 2003·European Journal of Biochemistry·María J RuanoAntonio Villalobo
May 10, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Trevor T HanselPeter J Barnes
Mar 16, 2004·Proceedings of the National Academy of Sciences of the United States of America·Zhiheng PeiMartin J Blaser
Aug 27, 2004·Nature·Eli PikarskyYinon Ben-Neriah
Jun 1, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M P MorelliF Ciardiello
Sep 15, 2005·International Journal of Cancer. Journal International Du Cancer·Mitsuhiko HanawaAkishi Ooi
Apr 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maarten L JanmaatGiuseppe Giaccone
Mar 8, 2007·Oncology Reports·Osamu TakahashiTetsuya Moriuchi
Apr 5, 2007·Journal of the National Cancer Institute·Elisabeth I HeathUNKNOWN Chemoprevention for Barrett's Esophagus Trial Research Group
Dec 8, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Linda A FeaginsRhonda F Souza
May 31, 2008·The American Journal of Gastroenterology·Joel H RubensteinJohn M Inadomi
Jun 17, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Rhonda F SouzaStuart Jon Spechler
Aug 16, 2008·Cancer Letters·Hui Ying ZhangRhonda F Souza
Oct 16, 2008·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Nelly E AvissarJeffrey H Peters
Jan 28, 2009·Scandinavian Journal of Gastroenterology·Fumitake IshiyamaTooru Shimosegawa
May 6, 2009·Molecular Carcinogenesis·Nadine VaninettiAlan G Casson
Jul 15, 2009·Current Opinion in Pharmacology·Mohamed M M Abdel-LatifDermot Kelleher
Oct 7, 2009·The American Journal of Gastroenterology·Farhad IslamiPaolo Boffetta

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Citations

Oct 28, 2016·Annals of the New York Academy of Sciences·Vincenzo Di PilatoPaolo Bechi
Jun 29, 2011·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Joost B SandersAartjan T F Beekman
Sep 21, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hao WangYulan Ruan
Oct 4, 2016·Experimental and Molecular Pathology·Wu YanDianchun Fang

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