Role of nitric oxide in the secondary expansion of a cortical brain lesion from cold injury

Journal of Neurotrauma
M StoffelA Baethmann

Abstract

We have investigated the role of nitric oxide (NO) as mediator of the secondary growth of a traumatic cortical necrosis. For this purpose, a highly standardized focal lesion of the brain was induced in 46 Sprague-Dawley rats by cold injury. Twenty-four hours later--the timepoint of maximal lesion spread--the animals were sacrificed and brains were removed for histomorphometry of the maximal necrosis area and volume. The animals were divided into five experimental groups. Group I received the NO donor L-arginine as i.v. bolus 10 min prior to trauma (300 mg/kg body weight; n = 10) and a second bolus of the same dosage intraperitoneally 1 h after trauma. Group II (n = 10)--serving as control of group I--was infused with an i.v. bolus of 1 mL/kg isotonic saline 10 min prior to and a subsequent bolus i.p. 1 h after trauma. Group III (n = 8) received 100 mg/kg b.w. of the inducible NOS (iNOS) inhibitor aminoguanidine (AG) 1 h before and 8 h after trauma by intraperitoneal route. Group IV was administered with the nitric oxide synthase (NOS) inhibitor N(G)-nitro-L-arginine (L-NNA; 100 mg/kg b.w., i.p.; n = 8); group V--the controls of group III and IV--was administered with isotonic saline (1 mL/kg b.w. i.p.; n = 10) 1 h before and 8 ...Continue Reading

References

Dec 18, 1992·Science·J S StamlerJ Loscalzo
Sep 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S YamamotoD J Reis
Sep 1, 1992·Annals of Neurology·T M DawsonS H Snyder
Jul 21, 1992·European Journal of Pharmacology·R R Trifiletti
Nov 12, 1991·European Journal of Pharmacology·J P NowickiB Scatton
Jan 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P J LindsbergG Feuerstein
Apr 1, 1989·Journal of Neurosurgery·A BaethmannO Kempski
Mar 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C IadecolaN A Lassen
Mar 1, 1994·Stroke; a Journal of Cerebral Circulation·F M Faraci, J E Brian
Jan 1, 1994·Annual Review of Biochemistry·D S Bredt, S H Snyder
Nov 1, 1994·Neuropharmacology·T DalkaraM A Moskowitz
Nov 1, 1994·Neuropharmacology·S A Lipton, J S Stamler
May 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T MalinskiM Chopp
Aug 1, 1996·Stroke; a Journal of Cerebral Circulation·K M CockroftK J Tracey
Sep 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Z HuangM A Moskowitz
Jan 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H FujitaA Gjedde
May 1, 1997·Journal of Neurotrauma·M StoffelA Baethmann
Nov 17, 1998·Journal of Neurosurgery·K WadaW D Dietrich
Jun 1, 1999·Journal of Neurosurgery·A DoğanR J Dempsey
Nov 24, 1999·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·B O Nilsson
Oct 1, 1958·Journal of Neuropathology and Experimental Neurology·I KLATZOE J LASKOWSKI

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Citations

Jun 28, 2002·Brain Research. Brain Research Reviews·Ronen R Leker, Esther Shohami
Sep 5, 1998·Brain Research. Brain Research Reviews·P F StahelT Kossmann
May 16, 2002·Neuroscience Letters·Michael StoffelNikolaus Plesnila
Jun 25, 2003·Neuroscience Letters·Nikolaus PlesnilaMichael Stoffel
May 7, 2002·Journal of Neurotrauma·Michael StoffelAlexander Baethmann
Jul 16, 2004·Journal of Neurotrauma·Michael StoffelNikolaus Plesnila
Apr 4, 2013·Antioxidants & Redox Signaling·Carolin CorneliusSalvatore Cuzzocrea
Mar 26, 2014·International Journal of Molecular Sciences·Carla S JungAndreas W Unterberg
Apr 8, 2015·Journal of Neuroscience Methods·Heiko J Luhmann
Feb 18, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hülya BayirPatrick M Kochanek
Jun 15, 2004·Brain Pathology·Leela CherianClaudia S Robertson
Apr 18, 2009·British Journal of Pharmacology·Valerie C Besson
Nov 5, 2014·Journal of Neurotrauma·Susanne M SchwarzmaierNikolaus Plesnila
Oct 3, 2012·Stem Cells International·Solomon O Ugoya, Jian Tu
Dec 28, 2002·Journal of Neuroscience Research·Vemuganti L Raghavendra RaoRobert J Dempsey
Apr 25, 2003·Cell and Tissue Research·Kayvon SalimiChristian Humpel

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