PMID: 9544425Apr 17, 1998Paper

Role of nitric oxide in tumor progression: lessons from experimental tumors

Cancer Metastasis Reviews
Peeyush K Lala, A Orucevic

Abstract

Nitric oxide (NO), a potent biological mediator, plays a key role in physiological as well as pathological processes, including inflammation and cancer. The role of NO in tumor biology remains incompletely understood. While a few reports indicate that the presence of NO in tumor cells or their microenvironment is detrimental to tumor cell survival and consequently their metastatic ability, a large body of clinical and experimental data suggest a promoting role of NO in tumor progression and metastasis. We suggest that tumor cells capable of very high levels of NO production die in vivo, and those producing or exposed to lower levels of NO, or capable of resisting NO-mediated injury undergo a clonal selection because of their survival advantage; they also utilize certain NO-mediated mechanisms for promotion of growth, invasion and metastasis. The possible mechanism(s) are: (a) a stimulatory effect on tumor cell invasiveness, (b) a promotion of tumor angiogenesis and blood flow in the tumor neovasculature, and (c) a suppression of host anti-tumor defense. In this review, we discuss these mechanisms on the basis of data derived from experimental models, in particular, a mouse mammary tumor model in which the expression of eNOS by ...Continue Reading

Citations

Feb 15, 2001·Veterinary Surgery : VS·L M Howe, H W Boothe
Jun 19, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·P G PhillipsW L Milonovich
Mar 10, 2001·Antioxidants & Redox Signaling·C M PayneH Garewal
Apr 6, 2002·Canadian Journal of Physiology and Pharmacology·Lorraine C JadeskiPeeyush K Lala
Mar 16, 2005·Experimental Lung Research·Alvin M Malkinson
Jun 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Xiangdong LeKeping Xie
Aug 17, 2006·Antioxidants & Redox Signaling·Lisa A RidnourJeffrey S Isenberg
Mar 7, 2009·World Journal of Gastroenterology : WJG·Nora A MohamadGabriela A Martín
Apr 13, 2010·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Aleksandra Bielawska-PohlSalem Chouaib
Apr 2, 2011·International Journal of Cancer. Journal International Du Cancer·Evangelos KogiasAstrid Weyerbrock
Aug 17, 2011·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Veena S GhalautRakesh Saharan
Mar 1, 2012·Journal of Cancer Research and Clinical Oncology·Enas A HamedDoaa W Maximous
Feb 18, 2015·Journal of Cancer Research and Clinical Oncology·Martin Alejandro KrasnapolskiAna María Eiján
Sep 18, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Q ShiK Xie
Feb 21, 2004·The Japanese Journal of Physiology·Chika MiyoshiNorio Ohshima
Dec 30, 2006·Cancer Chemotherapy and Pharmacology·Mingzhong ZhengElizabeth A Grimm
Apr 10, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Shafiul HaqueMohtashim Lohani
May 10, 2000·Bioscience, Biotechnology, and Biochemistry·G WanN Kato
Jun 6, 2000·British Journal of Cancer·M KorbelikD J Chaplin
Jul 31, 2001·International Journal of Cancer. Journal International Du Cancer·J G RozicP K Lala
Jul 2, 2005·World Journal of Gastroenterology : WJG·Guang-Yi WangJian-Hua Gu
Oct 2, 2003·International Journal of Cancer. Journal International Du Cancer·Josh D SilvertownThomas Klonisch
Dec 24, 2003·Acta Oncologica·Thomas HolmkvistMarieann Högman
Mar 16, 2006·Breast Cancer Research and Treatment·Lukas A HeflerRobert Zeillinger
Aug 12, 2005·World Journal of Gastroenterology : WJG·Somchai PinlaorShosuke Kawanishi
Oct 11, 2008·Fundamental & Clinical Pharmacology·G Y Perret, M Crépin
Oct 6, 2009·Journal of Food Science·M Viuda-MartosJ A Pérez-Alvarez
Mar 19, 2005·Marine Biotechnology·Detmer SipkemaRené H Wijffels
Sep 4, 2013·International Journal of Experimental Pathology·Ana BrankovićStanka Romac
Nov 21, 2014·American Journal of Physiology. Cell Physiology·Nuttida YongsanguanchaiPithi Chanvorachote
May 31, 2013·World Journal of Surgical Oncology·Sheetal Korde ChoudhariVaishali Joshi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Related Papers

International Journal of Cancer. Journal International Du Cancer
A OrucevicPeeyush K Lala
International Journal of Occupational Medicine and Environmental Health
Maciej Stepnik
Uspekhi fiziologicheskikh nauk
V N ZaporozhanV G Dubinina
© 2022 Meta ULC. All rights reserved