Role of nitric oxide (NO) in ocular inflammation

British Journal of Pharmacology
Z Y Wang, R Håkanson

Abstract

1. The actions of nitric oxide (NO) have been investigated in the rabbit eye, with particular emphasis on the relationship between NO and C-fibres and on those effects of NO that may be of importance in the inflammatory response to C-fibre stimulation. 2. The NO synthase inhibitor, NG-nitro-L-arginine (L-NAME; 10-200 mg kg-1), but not the inactive analogue D-NAME (200 mg kg-1), was found to block the inflammatory response induced by infrared irradiation of the iris in a dose-dependent manner. The inhibitory effects of L-NAME (200 mg kg-1) were partially reversed by L-arginine (500 mg kg-1), but not by D-arginine (500 mg kg-1). 3. L-NAME (200 mg kg-1) virtually abolished the ocular effects of intravitreal injection of calcitonin gene-related peptide (CGRP) (0.3 nmol). 4. The concentration of CGRP in aqueous humour from untreated rabbit eyes was 0.1 +/- 0.001 nmol l-1. Irradiation of the iris raised the CGRP concentration to 8.9 +/- 1.5 nmol l-1. L-NAME (200 mg kg-1) greatly suppressed the irradiation-evoked release of CGRP, the concentration in the aqueous humour being 1.2 +/- 0.2 nmol l-1 (P < 0.001). L-Arginine reversed the L-NAME-induced inhibition of release of CGRP, the concentration of CGRP in the aqueous humour being 9.7 ...Continue Reading

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Citations

Jul 28, 1999·European Journal of Pharmacology·M C Koss
Oct 17, 2006·Parasitology Today·K C CarterC W Roberts
May 11, 1999·Parasitology Today·F Roberts, R McLeod
May 14, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Kentaroh KamataMasahiko Usui
Apr 1, 2000·British Journal of Pharmacology·K MesslingerR F Schmidt
Oct 28, 1998·Environmental Health Perspectives·J B AllenC Privalle
Aug 25, 2010·Experimental Eye Research·Alex VielmaOliver Schmachtenberg
Dec 22, 1999·Parasite Immunology·F RobertsR McLeod
May 1, 1996·Stroke; a Journal of Cerebral Circulation·W G Mayhan, S P Didion
Nov 14, 2006·Parasite Immunology·L A JonesC W Roberts

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