Role of nitric oxide-related mechanisms in renal function in ageing rats

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
D TanC Caramelo

Abstract

The impaired renal function and vasodilatation that accompany age need to be re-addressed based upon the new knowledge concerning vascular nitric oxide (NO)-dependent systems. The present study examined the effects of age on the NO-related renal response. The study was performed in euvolaemic, conscious Wistar rats, aged 5 and 18 months. Renal function and haemodynamic measurements with fluorescent microspheres were employed to assess differences between groups. A first set of experiments showed that ageing rats had a reduced natriuretic and diuretic response to acetylcholine, whereas the response to sodium nitroprusside was preserved. In the same regard, a reduction of the renal functional effects of L-arginine (L-Arg) and L-glycine (L-Gly) was found in the older rats. In the ageing rats, these responses were accompanied by an enhanced effect of the L-Arg competitive analogue, NwNLA, which provoked a marked reduction of renal function. This effect of NwNLA was blocked by the simultaneous administration of a small dose of L-Arg in the ageing but not in the young rats. Systemic haemodynamic studies revealed that in ageing rats, NwNLA reduced renal blood flow and increased renal vascular resistances in a significantly higher prop...Continue Reading

Citations

Oct 31, 2000·Nutrition·C MacIntoshI M Chapman
Apr 13, 2006·Current Opinion in Nephrology and Hypertension·Carmine Zoccali, Jan T Kielstein
Oct 14, 2005·Kidney International·David A LongRichard J Johnson
Mar 31, 2004·Canadian Journal of Physiology and Pharmacology·R Tatchum-Talom, D S Martin
Sep 23, 2014·Vascular Cell·Maria Giovanna ScioliAugusto Orlandi
Feb 20, 2014·Ageing Research Reviews·Davide BolignanoCarmine Zoccali
Dec 13, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Michael J Kenney, Timothy I Musch
Oct 6, 2004·International Journal of Immunopathology and Pharmacology·M A De LutiisA Grilli

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