Abstract
The impaired renal function and vasodilatation that accompany age need to be re-addressed based upon the new knowledge concerning vascular nitric oxide (NO)-dependent systems. The present study examined the effects of age on the NO-related renal response. The study was performed in euvolaemic, conscious Wistar rats, aged 5 and 18 months. Renal function and haemodynamic measurements with fluorescent microspheres were employed to assess differences between groups. A first set of experiments showed that ageing rats had a reduced natriuretic and diuretic response to acetylcholine, whereas the response to sodium nitroprusside was preserved. In the same regard, a reduction of the renal functional effects of L-arginine (L-Arg) and L-glycine (L-Gly) was found in the older rats. In the ageing rats, these responses were accompanied by an enhanced effect of the L-Arg competitive analogue, NwNLA, which provoked a marked reduction of renal function. This effect of NwNLA was blocked by the simultaneous administration of a small dose of L-Arg in the ageing but not in the young rats. Systemic haemodynamic studies revealed that in ageing rats, NwNLA reduced renal blood flow and increased renal vascular resistances in a significantly higher prop...Continue Reading
Citations
Apr 3, 2001·General Pharmacology·R MaesoV Cachofeiro
Oct 31, 2000·Nutrition·C MacIntoshI M Chapman
Apr 14, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Antonello E RigamontiEugenio E Müller
Apr 13, 2006·Current Opinion in Nephrology and Hypertension·Carmine Zoccali, Jan T Kielstein
Oct 14, 2005·Kidney International·David A LongRichard J Johnson
Mar 31, 2004·Canadian Journal of Physiology and Pharmacology·R Tatchum-Talom, D S Martin
Mar 19, 2005·Pediatric Research·Frida Zaladek GilTerezila Machado Coimbra
Sep 23, 2014·Vascular Cell·Maria Giovanna ScioliAugusto Orlandi
Nov 9, 2000·Biochimica Et Biophysica Acta·P VerbekeH Bakala
Feb 20, 2014·Ageing Research Reviews·Davide BolignanoCarmine Zoccali
Dec 13, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Michael J Kenney, Timothy I Musch
Oct 16, 1999·Hypertension·N de las HerasV Lahera
Dec 11, 1999·Circulation Research·M A CastillaC Caramelo
Mar 15, 2006·Journal of Hypertension·Carmine Zoccali
Jul 16, 2011·Journal of Applied Physiology·Daniel M HiraiTimothy I Musch
Oct 6, 2004·International Journal of Immunopathology and Pharmacology·M A De LutiisA Grilli