Role of nitric oxide/cyclic GMP and cyclic AMP in beta3 adrenoceptor-chronotropic response

Journal of Molecular and Cellular Cardiology
Leonor Sterin-BordaEnri Borda

Abstract

In this study we determine different signaling pathways involved in beta(3) adrenoceptor (beta(3)-AR) dependent frequency stimulation in isolated rodent atria. Promiscuous coupling between different G-proteins and beta(3)-AR could explain the multiple functional effects of beta(3)-AR stimulation. We examine the mechanisms and functional consequences of dual adenylate cyclase and guanylate cyclase pathways coupling to beta(3)-AR in isolated rodent atria. The beta(3)-AR selective agonists ZD 7114 and ICI 215001 stimulated in a dose-dependent manner the contraction frequency that significantly correlated with cyclic AMP (cAMP) accumulation. Inhibition of adenylate cyclase shifted the chronotropic effect to the right. On the other hand, the ZD 7114 activity on frequency was enhanced by the inhibition of nitric oxide synthase (NOS) and soluble guanylate cyclase. This countervailing negative chronotropic nitric oxide-cyclic GMP (NO-cGMP) significantly correlated with the increase on NOS activity and cGMP accumulation. Current analysis showed a negative cross talk between cAMP chronotropic and NO-cGMP effects by inhibition of phospholipase C (PLC), calcium/calmodulin (CaM), protein kinase C (PKC), NOS isoforms and Gi-protein on the ef...Continue Reading

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Jan 30, 2002·British Journal of Pharmacology·Leonor Sterin-BordaEnri Borda

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Citations

May 2, 2013·Physiological Genomics·Alicia M EvangelistaElizabeth Murphy
Jul 24, 2013·Stress and Health : Journal of the International Society for the Investigation of Stress·Marcela LaukovaJaromir Myslivecek
Jul 14, 2010·Annales de cardiologie et d'angéiologie·C Gauthier, J N Trochu
Jul 19, 2015·European Journal of Pharmacology·Elizângela S OliveiraRosana A Bassani
Mar 27, 2015·Acta Physiologica·S ImbrognoM C Cerra
Aug 11, 2011·General and Comparative Endocrinology·Emma GiltrowMariann Rand-Weaver
Sep 19, 2019·The Journal of Experimental Biology·Serena LeoSandra Imbrogno
Aug 17, 2020·International Journal of Molecular Sciences·Laura van der SchoorMarcel A G van der Heyden

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