PMID: 8953468Dec 1, 1996Paper

Role of nitric oxide/cyclic GMP pathway in the inhibitory effect of GABA and dopamine on prolactin release

Journal of Neuroendocrinology
Beatriz H DuvilanskiA Seilicovich

Abstract

The anterior pituitary gland is a site of nitric oxide (NO) production and action, suggesting a local regulatory function. We recently reported that NO inhibits in vitro prolactin release. The aim of the present study was to establish the mechanism of action of NO on prolactin release and to determine whether NO is involved in the inhibitory effect of GABA on prolactin release. Since NO exerts its action through cGMP by activating guanylate cyclase in different tissues, we examined the effect of sodium nitroprusside (NP), a NO releaser, on intrapituitary cGMP levels. Incubation of anterior pituitary glands with 0.5 mM NP 4-fold increased intrapituitary cGMP content, but decreased intrapituitary cAMP levels. In addition, we studied the effect of NP on prolactin release in the presence of LY 83583, an inhibitor of guanylate cyclase activity and 3-isobutyl-1-methylxanthine (IBMX), an inhibitor of phosphodiesterase activity. 10 microM LY 83583 and 0.5 mM IBMX blocked the inhibitory effect of NP on prolactin release. (10(-3) M) 8Br-cGMP, an analogue of cGMP, mimicked the effect of NP on prolactin release. On the other hand, NO seems to be involved in the inhibitory effect of GABA on prolactin release since hemoglobin, a scavenger of...Continue Reading

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Citations

May 27, 2011·Neuroscience Bulletin·Ming-Yu Jiang, De-Pei Cai
Jan 24, 2004·Life Sciences·Anunciación LafuenteAna I Esquifino
Feb 13, 2001·Molecular and Cellular Endocrinology·M O VelardezB H Duvilanski
Feb 18, 1999·Molecular and Cellular Endocrinology·B H DuvilanskiD Becu-Villalobos
Jun 14, 2000·General and Comparative Endocrinology·A D Uretsky, J P Chang
Sep 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·S KaranthS M McCann
Sep 30, 2004·Free Radical Biology & Medicine·Ariel H B PoliandriBeatriz H Duvilanski
May 18, 2016·Nigerian Medical Journal : Journal of the Nigeria Medical Association·Uduak Akpan Okon, Ikponoabasi Ibanga Utuk
Mar 31, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·Jill M RussellP Callahan
Nov 20, 1998·Journal of Cardiovascular Pharmacology·R LiuM Kaufmann
Jan 5, 1999·The Journal of Biological Chemistry·E A RatovitskiC J Lowenstein
Oct 4, 2000·Physiological Reviews·M E FreemanG Nagy

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