Role of nitrosative and oxidative stress in neuropathy in patients with type 2 diabetes mellitus.

Journal of Neurosciences in Rural Practice
Marwan S Al-NimerFatima S Ali

Abstract

Evidences of oxidative and/or nitrosative stress in type 2 diabetes mellitus were demonstrated in experimental and human studies. This study is aimed to assess the serum peroxynitrite and oxidized lipoproteins in patients with type 2 diabetes mellitus presented with clinical and laboratory evidences of peripheral neuropathy. Eighty four patients with type 2 diabetes mellitus (51 of them had neuropathy) and 31 apparent healthy subjects were studied in the unit of neurophysiology at the University Hospital of Medical College, Al-Nahrin University in Baghdad, Iraq. Neuropathy total symptom score (NTSS), neuropathy impairment score in the lower leg (NIS-LL), and nerve conduction velocity of sensory (ulnar and sural) and motor (ulnar and common peroneal) nerves were used to assess the neuropathy. Fasting venous blood was obtained from each participant for the determination of serum glucose and oxidized lipoproteins. The electrophysiology study revealed significant decrease in conduction velocity of ulnar (sensory and motor components), sural, and common peroneal nerves in diabetic neuropathy compared to diabetics without neuropathy and healthy subjects. Significant high level of serum peroxynitrite was found in diabetic patients wit...Continue Reading

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Citations

Jun 22, 2012·Molecular Biology Reports·Jacek KasznickiJozef Drzewoski
Nov 26, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Adem AhlatciKadir Cinar
Jun 26, 2014·Cutaneous and Ocular Toxicology·Seyithan TaysiMehmet Tarakcioglu
Jul 7, 2015·Journal of Diabetes and Its Complications·Mercedes Molina MendezJose T Real
Nov 13, 2015·Journal of Diabetes and Metabolic Disorders·Ozra Tabatabaei-MalazyBagher Larijani
Apr 28, 2017·Nature Reviews. Neurology·Michael P Collins, Robert D Hadden
Aug 5, 2020·The Journal of Obstetrics and Gynaecology Research·Senol KalyoncuSeyithan Taysi
Jun 6, 2013·American Journal of Physiology. Endocrinology and Metabolism·Sergey LupachykMark A Yorek

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