PMID: 20647646Jul 22, 2010Paper

Role of non-invasive ventilation in managing life-threatening acute exacerbation of interstitial pneumonia

Internal Medicine
Keisuke TomiiKyosuke Ishihara

Abstract

Invasive mechanical ventilation (IMV) is not effective for acute exacerbation of interstitial pneumonia (AE-IP); however, the role of non-invasive ventilation (NIV) for this condition remains unknown. Comparisons were made for two periods: before (October 2001 - September 2003) and after (October 2004 - September 2006) the introduction of NIV as the primary method of mechanical ventilation for AE-IP. We retrospectively screened emergent admissions and enrolled consecutively those patients with AE-IP who had acutely worsening hypoxemia with new infiltrates, background chronic interstitial CT changes, and no findings suggestive of other diseases. The two periods were compared primarily for 60-day survival and secondarily for other outcomes associated with mechanical ventilation. Medical records were retrieved for 11 episodes in 11 patients identified from 485 pre-NIV records and 27 episodes in 22 patients from 859 post-NIV records. Five patients required IMV in the earlier cohort and 9 patients received NIV in the later cohort. Although there was no difference in the PaO(2)/FiO(2) ratio on admission (167 vs. 139), the 60-day survival rate for all episodes in the later cohort was better than in the earlier cohort (27% vs. 65%, p=0...Continue Reading

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Sep 3, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Toshiki YokoyamaKeishi Kubo
Feb 18, 2016·Respiratory Investigation·Yukihiro HorioKoichiro Asano
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