Role of Nonneuronal TRPV4 Signaling in Inflammatory Processes

Advances in Pharmacology
Pradeep RajasekharNicholas A Veldhuis

Abstract

Transient receptor potential (TRP) ion channels are important signaling components in nociceptive and inflammatory pathways. This is attributed to their ability to function as polymodal sensors of environmental stimuli (chemical and mechanical) and as effector molecules in receptor signaling pathways. TRP vanilloid 4 (TRPV4) is a nonselective cation channel that is activated by multiple endogenous stimuli including shear stress, membrane stretch, and arachidonic acid metabolites. TRPV4 contributes to many important physiological processes and dysregulation of its activity is associated with chronic conditions of metabolism, inflammation, peripheral neuropathies, musculoskeletal development, and cardiovascular regulation. Mechanosensory and receptor- or lipid-mediated signaling functions of TRPV4 have historically been attributed to central and peripheral neurons. However, with the development of potent and selective pharmacological tools, transgenic mice and improved molecular and imaging techniques, many new roles for TRPV4 have been revealed in nonneuronal cells. In this chapter, we discuss these recent findings and highlight the need for greater characterization of TRPV4-mediated signaling in nonneuronal cell types that are ...Continue Reading

Citations

Apr 14, 2019·Molecular & Cellular Proteomics : MCP·Chan Hyun NaAkhilesh Pandey
Aug 15, 2018·Toxins·Brett BoonenKarel Talavera
Feb 8, 2019·Frontiers in Pharmacology·Sara BaratchiPeter McIntyre
Jul 1, 2019·Molecular & Cellular Proteomics : MCP·Chan Hyun NaAkhilesh Pandey

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Advanced Imaging of Cellular Signaling

Cell signaling is a vital mechanism for communication within cells and outside with the environment. Several different signaling pathways have been found and advanced imaging techniques are being developed to visualize the molecules involved in these signaling pathways. Find the latest research in advanced imaging of cellular signaling here.

Related Papers

Naunyn-Schmiedeberg's Archives of Pharmacology
Neil M GoldenbergWolfgang M Kuebler
Methods in Molecular Biology
Aniello Schiano Moriello, Luciano De Petrocellis
Recent Patents on CNS Drug Discovery
Louise A Roberts, Mark Connor
© 2022 Meta ULC. All rights reserved