Role of nuclear receptor corepressor RIP140 in metabolic syndrome

Biochimica Et Biophysica Acta
Meritxell RosellMalcolm G Parker


Obesity and its associated complications, which can lead to the development of metabolic syndrome, are a worldwide major public health concern especially in developed countries where they have a very high prevalence. RIP140 is a nuclear coregulator with a pivotal role in controlling lipid and glucose metabolism. Genetically manipulated mice devoid of RIP140 are lean with increased oxygen consumption and are resistant to high-fat diet-induced obesity and hepatic steatosis with improved insulin sensitivity. Moreover, white adipocytes with targeted disruption of RIP140 express genes characteristic of brown fat including CIDEA and UCP1 while skeletal muscles show a shift in fibre type composition enriched in more oxidative fibres. Thus, RIP140 is a potential therapeutic target in metabolic disorders. In this article we will review the role of RIP140 in tissues relevant to the appearance and progression of the metabolic syndrome and discuss how the manipulation of RIP140 levels or activity might represent a therapeutic approach to combat obesity and associated metabolic disorders. This article is part of a Special Issue entitled: Translating nuclear receptors from health to disease.


Jun 8, 2013·Trends in Endocrinology and Metabolism : TEM·Jaya NautiyalMalcolm G Parker
Jun 16, 2012·The Journal of Pharmacology and Experimental Therapeutics·Laura A A Gilliam, P Darrell Neufer
Dec 12, 2012·The Journal of Clinical Investigation·Amine ToubalNicolas Venteclef
Feb 28, 2016·Pulmonary Pharmacology & Therapeutics·Chuanjiang LeiJianchun Wang
Mar 31, 2015·Cell·Jonathan R Brestoff, David Artis
Jun 19, 2013·Molecular Systems Biology·Zeynep Madak-ErdoganBenita S Katzenellenbogen
May 6, 2016·Stem Cells International·Chuanhai ZhangWanzhu Jin
Oct 14, 2016·Journal of Cellular Physiology·Tanes I LimaLeonardo R Silveira
Jan 21, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·P BaskaranB Thyagarajan
Dec 18, 2012·Cellular & Molecular Immunology·Hun Taeg Chung
Aug 24, 2019·Cardiovascular & Hematological Disorders Drug Targets·Faez Almohsen, Subh S Al-Mudallal
Apr 18, 2017·Oncogene·S JalaguierV Cavaillès
Jan 12, 2017·Journal of Molecular Endocrinology·Jaya Nautiyal
Feb 14, 2017·The Journal of Clinical Investigation·Rick B Vega, Daniel P Kelly
Sep 30, 2017·Annual Review of Pharmacology and Toxicology·Vincenzo SorrentinoJohan Auwerx


Dec 19, 1996·Nature·A J Bannister, T Kouzarides
May 16, 1998·The Journal of Biological Chemistry·D C HarnishS K Karathanasis
Oct 26, 1999·The Journal of Biological Chemistry·C H Lee, L N Wei
Sep 28, 2000·The Journal of Biological Chemistry·L N WeiM Farooqui
Feb 8, 2002·The New England Journal of Medicine·William C KnowlerDiabetes Prevention Program Research Group
May 15, 2002·American Journal of Physiology. Endocrinology and Metabolism·Charles J TannerJoseph A Houmard
Feb 20, 2003·Trends in Endocrinology and Metabolism : TEM·Olli Vuolteenaho, Heikki Ruskoaho
Aug 28, 2003·The Journal of Biological Chemistry·Jeffrey W RyderJuleen R Zierath
Dec 18, 2003·The Journal of Clinical Investigation·Stuart P WeisbergAnthony W Ferrante
Dec 25, 2003·Diabetes·John M AdamsLawrence J Mandarino
Jan 13, 2004·Physiological Reviews·Barbara Cannon, Jan Nedergaard
May 25, 2004·Proceedings of the National Academy of Sciences of the United States of America·Göran LeonardssonMalcolm G Parker
Aug 6, 2004·The Proceedings of the Nutrition Society·Matthew W Hulver, G Lynis Dohm
May 10, 2005·Molecular & Cellular Proteomics : MCP·M D Mostaqul Huq, Li-Na Wei
Jun 7, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S Cinti
Jun 25, 2005·Molecular Endocrinology·J Dinny GrahamChristine L Clarke
Aug 12, 2005·Molecular & Cellular Proteomics : MCP·Pawan GuptaLi-Na Wei
Aug 23, 2005·Biochemical and Biophysical Research Communications·Gaël Jean-BaptisteMichael T Greenwood
Oct 18, 2005·Molecular and Cellular Biology·Mark ChristianMalcolm G Parker
Feb 9, 2006·American Journal of Physiology. Endocrinology and Metabolism·Clinton R BruceDavid J Dyck
Mar 11, 2006·Molecular Endocrinology·Sophie CarascossaS Jalaguier
Apr 1, 2006·Progress in Lipid Research·Xuemin WangRuth Welti
Apr 8, 2006·Physiological Reviews·Béatrice DesvergneWalter Wahli
Apr 20, 2006·Endocrine·George A Bray, Tracy Bellanger
Jun 8, 2006·Annual Review of Biochemistry·Rhonda Bassel-Duby, Eric N Olson
Jun 27, 2006·Molecular Genetics and Metabolism·Sanford R Sampson, Denise R Cooper
Aug 11, 2006·The Biochemical Journal·Jacob B Hansen, Karsten Kristiansen

Related Concepts

Metabolic Process, Cellular
Establishment and Maintenance of Localization
Response to Cold
Diabetes Mellitus, Non-Insulin-Dependent
NRIP1 wt Allele
Brown Fat
Biochemical Pathway
Insulin Sensitivity
PPARA wt Allele

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