Role of nucleus of the solitary tract noradrenergic neurons in post-stress cardiovascular and hormonal control in male rats

Stress : the International Journal on the Biology of Stress
Jana Bundzikova-OsackaJ P Herman

Abstract

Chronic stress causes hypothalamo-pituitary-adrenal (HPA) axis hyperactivity and cardiovascular dyshomeostasis. Noradrenergic (NA) neurons in the nucleus of the solitary tract (NTS) are considered to play a role in these changes. In this study, we tested the hypothesis that NTS NA A2 neurons are required for cardiovascular and HPA axis responses to both acute and chronic stress. Adult male rats received bilateral microinjection into the NTS of 6-hydroxydopamine (6-OHDA) to lesion A2 neurons [cardiovascular study, n = 5; HPA study, n = 5] or vehicle [cardiovascular study, n = 6; HPA study, n = 4]. Rats were exposed to acute restraint stress followed by 14 d of chronic variable stress (CVS). On the last day of testing, rats were placed in a novel elevated plus maze (EPM) to test post-CVS stress responses. Lesions of NTS A2 neurons reduced the tachycardic response to acute restraint, confirming that A2 neurons promote sympathetic activation following acute stress. In addition, CVS increased the ratio of low-frequency to high-frequency power for heart rate variability, indicative of sympathovagal imbalance, and this effect was significantly attenuated by 6-OHDA lesion. Lesions of NTS A2 neurons reduced acute restraint-induced corti...Continue Reading

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Citations

Oct 30, 2016·Physiology & Behavior·Brent Myers
Feb 24, 2018·The Journal of Comparative Neurology·Aina Luque-GarcíaJoana Martínez-Ricós
Sep 24, 2020·American Journal of Physiology. Cell Physiology·Forrest J RagozzinoJames H Peters
Dec 22, 2020·Stress : the International Journal on the Biology of Stress·James P HermanEvelin M Cotella
Apr 25, 2017·Brain Research·Laurie PhamRussell D Romeo

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