Abstract
Preoperative chemoradiation therapy (CRT) potentially benefits a subgroup of patients with esophageal cancer. The ability to administer aggressive CRT may depend on the initial nutritional status and the ability to sustain nutrition during therapy. Parenteral nutrition support during CRT may lead to complications that limit its usefulness and negate any potential benefit. Data were analyzed to evaluate the role of parenteral nutrition support (PNS) in patients receiving CRT. Forty-five consecutive patients with locoregional esophageal cancer, enrolled in a phase I/II trial of induction CRT, were analyzed. On the basis of the nutrition support received, two groups were defined as follows: group I (with PNS, n = 30) and group II (without PNS, n = 15). Results were compared in terms of chemotherapy (CT) dose tolerated, morbidity of CRT, response rates, and surgical outcome in groups with and without PNS. The two groups were comparable for demographic data, stage and site of disease, and performance status. There was no significant difference between the groups in the nutritional parameters (weight and serum albumin) before and after CRT. Group I patients received significantly more (% of total calculated dose) CT compared with gro...Continue Reading
References
Sep 1, 1979·Postgraduate Medical Journal·R V HeatleyM H Lewis
Feb 1, 1977·The British Journal of Surgery·K MoghissiE A Dawes
May 1, 1989·Annals of Internal Medicine
Jul 1, 1985·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R S WeinerF A Hoffman
Feb 1, 1986·World Journal of Surgery·J M MüllerW Holzmüller
Sep 1, 1984·Annals of Internal Medicine·M ShikeK N Jeejeebhoy
Jan 9, 1982·Lancet·J M MüllerH Pichlmaier
May 1, 1984·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R L Koretz
May 1, 1984·JPEN. Journal of Parenteral and Enteral Nutrition·S S Donaldson
Feb 1, 1981·The British Journal of Surgery·S T LimG B Ong
Aug 13, 1981·The New England Journal of Medicine·M F Brennan
Oct 1, 1994·Annals of Surgery·M F BrennanM Shike
Apr 1, 1994·Cancer·E Le PriseB Launois
Feb 1, 1993·Annals of Surgery·R SandströmK Lundholm
Jun 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A A ForastiereM Zahurak
Jan 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B A BatesJ E Tepper
Citations
Jun 26, 2012·Current Gastroenterology Reports·Keith R Miller, Matthew C Bozeman
Jun 3, 2014·Trials·David J BowreyKaren Smith
May 31, 2011·The Surgical Clinics of North America·J Alexander Palesty, Stanley J Dudrick
Sep 29, 2015·The Journal of Thoracic and Cardiovascular Surgery·Yinin HuBenjamin D Kozower
Apr 18, 2009·Journal of Surgical Oncology·Matthew R Bower, Robert C G Martin
Oct 1, 2014·Annals of the New York Academy of Sciences·Mahesh Kumar Goenka, Russell E White
Aug 2, 2011·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Federico Bozzetti
Jun 12, 2013·Critical Reviews in Oncology/hematology·Federico Bozzetti
Jun 12, 2010·International Journal of Surgery·Moneer A AbdelgadirMohamed ElMakki Ahmed
Aug 5, 2006·Digestive Surgery·I J M Han-GeurtsH W Tilanus
Apr 28, 2001·Drugs·G MantovaniC Madeddu
Oct 11, 2005·QJM : Monthly Journal of the Association of Physicians·J N GordonP M Goggin
Mar 22, 2007·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Catherine M Crill, Richard A Helms
Aug 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·J J Body
Jul 23, 1999·Current Opinion in Oncology·J J Body
Aug 14, 2013·Pharmacotherapy·Shadi FarsaeiMohammad Taghi Beigmohammadi
Apr 12, 2000·Cancer Control : Journal of the Moffitt Cancer Center·D Riccardi, K Allen
Oct 7, 2006·Current Opinion in Gastroenterology·P Kitchen, A Forbes
Oct 22, 2020·Nutrients·Rishi JainEfrat Dotan
May 11, 2021·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Yuqin CaoHecheng Li
Oct 29, 2021·Food & Function·Dinuerguli YishakeHui-Lian Zhu