Role of nutritional vitamin D in osteoporosis treatment

Clinica Chimica Acta; International Journal of Clinical Chemistry
Yi-Chou HouKuo-Cheng Lu

Abstract

Osteoporosis is a systemic skeletal disorder characterized by a decrease in bone mass and microarchitectural deterioration of bone tissue. The World Health Organization has defined osteoporosis as a decrease in bone mass (50%) and bony quality (50%). Vitamin D, a steroid hormone, is crucial for skeletal health and in mineral metabolism. Its direct action on osteoblasts and osteoclasts and interaction with nonskeletal tissues help in maintaining a balance between bone turnover and bone growth. Vitamin D affects the activity of osteoblasts, osteoclasts, and osteocytes, suggesting that it affects bone formation, bone resorption, and bone quality. At physiological concentrations, active vitamin D maintains a normal rate of bone resorption and formation through the RANKL/OPG signal. However, active vitamin D at pharmacological concentration inhibits bone resorption at a higher rate than that of bone formation, which influences the bone quality and quantity. Nutritional vitamin D rather than active vitamin D activates osteoblasts and maintains serum 25(OH)D3 concentration. Despite many unanswered questions, much data support nutritional vitamin D use in osteoporosis patients. This article emphasizes the role of nutritional vitamin D ...Continue Reading

Citations

Sep 8, 2019·Nutrients·Kun-Mo LinKuo-Cheng Lu
Dec 20, 2018·Nutrients·Luca Dalle CarbonareAngelo Pietrobelli
Jan 20, 2019·International Journal of Molecular Sciences·Fabiana MammoliChiara Frassineti
Jun 12, 2021·Journal of Bone and Mineral Metabolism·Chong ZhengKewei Li
Sep 28, 2021·Frontiers in Physiology·Kathryn H AllibandJohn M Brameld

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