Role of ocular albinism type 1 (OA1) GPCR in Asian gypsy moth development and transcriptional expression of heat-shock protein genes

Pesticide Biochemistry and Physiology
LiLi SunChuanWang Cao

Abstract

The ocular albinism type 1 gene, named OA1, is a coding pigment cell-specific G protein-coupled receptor exclusively localized in intracellular organelles. However, the function of OA1 in insects remains generally unknown. In the present study, we explore for the first time the function of LdOA1 in the Asian gypsy moth, Lymantria dispar. To identify the function of LdOA1 gene in the development and growth of the Asian gypsy moth, the LdOA1 gene in third instar larvae was knocked down by RNAi. Compared with the controls, the knockdown of LdOA1 increased larval mortality but did not significantly affect their utilization of nutrition. Moreover, LdOA1 was stably transformed into the third chromosome of Drosophila melanogaster. The LdOA1 gene in the transformed D. melanogaster modulated the expression of heat-shock protein (hsp) and increased the expression of hsp genes under deltamethrin stress, which indicates that LdOA1 is involved in the regulation of hsp gene expression. These results deepen our understanding of the molecular function of OA1 in insects.

References

Aug 1, 1993·Pigment Cell Research·K UrabeV J Hearing
Aug 9, 1996·The Journal of Biological Chemistry·Y MinamiF U Hartl
Aug 24, 2001·Archives of Insect Biochemistry and Physiology·J V Broeck
Feb 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·Patricia J WittkoppSean B Carroll
Jan 22, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Geneviève MorrowRobert M Tanguay
Sep 26, 2006·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Jae-Kyoung ShimKyeong-Yeoll Lee
Sep 20, 2007·Nature Reviews. Molecular Cell Biology·Graça Raposo, Michael S Marks
Nov 4, 2008·Seminars in Cell & Developmental Biology·Patricia J Wittkopp, Patrícia Beldade
Nov 13, 2008·Molecular and Cellular Endocrinology·Sadani N CoorayAdrian J L Clark
Dec 24, 2009·Current Pharmaceutical Design·Irina G Tikhonova, Stefano Costanzi
Apr 13, 2010·The International Journal of Biochemistry & Cell Biology·Maria Vittoria Schiaffino
Aug 3, 2010·Journal of Insect Science·David K WillisWalter G Goodman
Jan 5, 2011·Nature Reviews. Drug Discovery·Rosamaria Lappano, Marcello Maggiolini
Jul 7, 2011·Proceedings of the National Academy of Sciences of the United States of America·Francesca GiordanoGraça Raposo
Sep 1, 2009·Environmental Toxicology and Pharmacology·Tatsuya YoshimiTakashi Miura
Dec 20, 2011·The FEBS Journal·Franziska KriegenburgRasmus Hartmann-Petersen
May 12, 2012·Genetics and Molecular Research : GMR·L M MagdalenaL Gavrila
Nov 17, 2012·Developmental Cell·Monica C Rodrigo-Brenni, Ramanujan S Hegde
Jan 19, 2013·Circulation Research·Xuejun WangHuabo Su
Aug 24, 2013·The Journal of Biological Chemistry·Christian BergmayrChristian W Gruber

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