Role of oil extract of garlic (Allium sativum Linn.) on intestinal transference of calcium and its possible correlation with preservation of skeletal health in an ovariectomized rat model of osteoporosis

Phytotherapy Research : PTR
Maitrayee MukherjeeChandan Mitra

Abstract

The present study was undertaken to examine the effects of an oil extract of garlic on the in vivo intestinal transference of calcium, and also to verify its role in maintaining the bone mineral content and bone tensile strength in an ovariectomized rat model of osteoporosis. The results suggest that, in this experimental model, oil extract of garlic promotes intestinal transference of calcium by modulating the activities of both intestinal alkaline phosphatase and Ca(2+) activated ATPase. Also the observed low bone mineral content and low bone tensile strength in these rats were significantly restored by garlic oil supplementation. Further, garlic oil supplementation was able to revive partially the bilateral ovariectomy-induced decrease in the serum estrogen titer. The serum parathyroid hormone level, however, was found unaltered in these rats. The garlic oil supplemented partial recovery in serum estrogen titer in bilaterally ovariectomized rat was found to be persistently associated with enhanced calcium transference and better preservation of bone mineral content. The results of this study propose that the phytoestrogenic efficacy of an oil extract of garlic prevents ovarian hormone deficiency induced bone mineral loss pos...Continue Reading

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Citations

Feb 9, 2012·Bioscience, Biotechnology, and Biochemistry·Masatoshi YamaguchiKazuhiko Arimori
Jul 27, 2011·Environmental Toxicology and Pharmacology·Sangita MajumdarChandan Mitra
Jun 15, 2012·Animal Science Journal = Nihon Chikusan Gakkaihō·Michihisa UedaShinichi Kume
Mar 23, 2012·Animal Science Journal = Nihon Chikusan Gakkaihō·Hinako OtsukaShinichi Kume
Oct 9, 2012·Journal of Dietary Supplements·Hassan Mozaffari-KhosraviMohammad Hossein Fllahzadeh
Nov 16, 2006·Phytotherapy Research : PTR·Sophie E PutnamElizabeth M Williamson
Mar 4, 2021·Acta Biomaterialia·Susmita BoseDishary Banerjee
Mar 20, 2021·The Journal of Pharmacy and Pharmacology·Nadire EserMustafa Cicek
May 30, 2021·Biological Trace Element Research·Aliaa Ezz El ArabMohamad Taha Abdelrahman
Aug 10, 2021·Frontiers in Pharmacology·Yanming HaoChong Li

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