Abstract
Vasogenic brain edema after subarachnoid hemorrhage (SAH) is an independent risk factor for death and poor prognosis. Disruption of the blood-brain barrier (BBB) is the main cause of vasogenic brain edema induced by SAH. Oleanolic acid (OA) is a natural pentacyclic triterpenoid with various biological functions. Previous studies have shown that prophylactic administration of OA could prevent the BBB disruption in autoimmune encephalomyelitis mice. In this context, we speculate that OA may play a neuroprotective role by protecting the integrity of the BBB and reducing vasogenic cerebral edema after SAH. To validate this hypothesis, a SAH model was established on Sprague Dawley rats using a standard intravascular puncture model. The effects of OA on various physiological indexes were observed, including SAH grades, mortality, neurological function score, brain edema and BBB permeability. Related proteins of the brain endothelial cell junction complex were also detected, including tight junctions (TJs) and adherent junctions (AJs). Results showed that OA significantly reduced the permeability of BBB and relieved brain edema by increasing protein expression of TJs and AJs, and decreased the SAH grades by increasing the protein expr...Continue Reading
Citations
Jan 21, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lingpeng ZhuTing-Ting Wei
Jun 11, 2020·World Journal of Clinical Cases·Alaattin Sen
Jan 10, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Fuyou GuoShixiong Lei
Apr 23, 2020·Frontiers in Cellular Neuroscience·Yuanjian FangJianmin Zhang
Jun 11, 2019·Frontiers in Cellular Neuroscience·Hana ParkTae-Cheon Kang
Feb 15, 2019·Neural Regeneration Research·Yang WangChao-Shi Niu
Jan 28, 2020·Drug Metabolism Reviews·Jie YangJingqing Zhang
May 24, 2020·Neurochemical Research·Fang WangZhi Dong
Jan 7, 2021·Acta neurochirurgica·Michael AmooMohsen Javadpour
Oct 8, 2020·Microbiology and Immunology·Min YuJiangmin Zhao
Dec 22, 2020·European Journal of Pharmacology·Yuwei HanGuobiao Liang
Nov 25, 2020·Antioxidants·Wei-Cheng JiangShaw-Fang Yet
Dec 12, 2020·Acta Pharmacologica Sinica·Cheng-di LiuGuan-Hua Du
May 29, 2021·International Journal of Dental Hygiene·Gloria M RamírezGiuseppe A Romito
Nov 26, 2021·Drug Development Research·Yuwei HanGuobiao Liang