Role of oligodendrocyte-neurovascular unit in white matter repair

Neuroscience Letters
Gen HamanakaKen Arai

Abstract

White matter injury caused by acute or chronic neuropathologies is a major characteristic of many CNS diseases, and an effective treatment is still out of our reach. White matter damage is associated with the collapse of the axon-myelin complex and with blood-brain barrier (BBB) breakdown, which results in disruption of white matter function. While white matter damage cannot completely resolve spontaneously, some compensative responses may occur after the injury. Oligodendrocyte lineage cells perform critical functions in repairing damaged white matter. In this mini-review, we will focus on the reparative actions of the oligodendrocytes, and highlight the important role of oligodendrocyte lineage cells in brain recovery after injury.

Citations

Nov 18, 2018·Cell Transplantation·Jinwei PangYong Jiang
Apr 15, 2021·GeroScience·Behnam Sabayan, Rudi G J Westendorp
Apr 30, 2021·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Akiko NishiyamaFriederike Pfeiffer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Related Papers

Nihon yakurigaku zasshi. Folia pharmacologica Japonica
Shinsuke Nakagawa, Masami Niwa
Journal of Neurology, Neurosurgery, and Psychiatry
O TomkinsA Friedman
Research Communications in Chemical Pathology and Pharmacology
T M FarberN B Fizette
© 2022 Meta ULC. All rights reserved