Role of omega-3 polyunsaturated fatty acids in preventing gastrointestinal cancers: current status and future perspectives

Expert Review of Anticancer Therapy
Ho-Jae LeeKi Baik Hahm

Abstract

Although inflammation is defensive and healing process that maintains organ homeostasis, unresolved inflammation can lead to diseases. Polyunsaturated fatty acids (PUFAs), especially n-6 PUFAs abundant in Western diet, are precursors of pro-inflammatory mediators, whereas n-3 PUFAs possess anti-inflammatory properties. Therefore, interest in the cancer-preventive effect of n-3 PUFAs is increasing. Areas covered: We have observed significant reductions of gastrointestinal tumorigenesis in the Fat-1 transgenic mouse as evidenced that the decrease in Helicobacter pylori-infected gastric tumorigenesis, colon, biliary, and pancreatic cancer was seen in Fat-1 mice producing n-3 PUFAs. However, despite many studies showing benefits, evidence-based medicine regarding molecular pathology, epidemiology, and clinical achievement of cancer prevention of n-3 PUFAs are still limited. Expert commentary: Primary deficiency of eicosapentaenoic acids and docosahexaenoic acids in Western diets can explain the risk of cancer development and the importance of n-3/n-6 PUFA ratio in reducing cancer risk. Alteration of cell membrane composition during carcinogenesis is particularly important, due to increased rate of lipid/cholesterol synthesis in can...Continue Reading

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Citations

Feb 8, 2020·Nanomedicine·Qianyu ZhangXuefeng Xia
Jun 18, 2020·Journal of Food Biochemistry·Tanu Sharma, Chandi C Mandal
Mar 20, 2020·Journal of Nutrition and Metabolism·Sara Jarmakiewicz-CzajaRafał Filip
Sep 5, 2020·World Journal of Surgical Oncology·Zhongjie HuangXiaoping Huang
Jul 18, 2019·Genes·Antonio PaoliFabio Piccini
May 12, 2020·The Science of the Total Environment·Evgenios Agathokleous, Edward J Calabrese
May 25, 2021·Journal of Clinical Biochemistry and Nutrition·Jong Min ParkKi Baik Hahm

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