Role of orexin-1 receptor mechanisms on compulsive food consumption in a model of binge eating in female rats.

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Laura PiccoliMauro Corsi

Abstract

Orexins (OX) and their receptors (OXR) modulate feeding, arousal, stress, and drug abuse. Neural systems that motivate and reinforce drug abuse may also underlie compulsive food seeking and intake. Therefore, the effects of GSK1059865 (5-bromo-N-[(2S,5S)-1-(3-fluoro-2-methoxybenzoyl)-5-methylpiperidin-2-yl]methyl-pyridin-2-amine), a selective OX(1)R antagonist, JNJ-10397049 (N-(2,4-dibromophenyl)-N'-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]urea), a selective OX(2)R antagonist, and SB-649868 (N-[((2S)-1-{[5-(4-fluorophenyl)-2-methyl-1,3-thiazol-4-yl]carbonyl}-2-piperidinyl)methyl]-1-benzofuran-4-carboxamide), a dual OX(1)/OX(2)R antagonist were evaluated in a binge eating (BE) model in female rats. BE of highly palatable food (HPF) was evoked by three cycles of food restriction followed by stress, elicited by exposing rats to HPF, but preventing them from having access to it for 15 min. Pharmacokinetic assessments of all compounds were obtained under the same experimental conditions used for the behavioral experiments. Topiramate was used as the reference compound as it selectively blocks BE in rats and humans. Dose-related thresholds for sleep-inducing effects of the OXR antagonists were measured using polysomnography in ...Continue Reading

References

Nov 1, 1985·The American Journal of Clinical Nutrition·B G Hoebel
May 1, 1994·Journal of Abnormal Psychology·J PolivyA L Beal
Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·L de LeceaJ G Sutcliffe
Jun 20, 1998·Science·B T Walsh, M J Devlin
Nov 20, 1998·FEBS Letters·P TrivediX M Guan
Mar 17, 2000·Journal of Psychosomatic Research·J WardleZ Lipsey
Jun 1, 2000·The American Journal of Psychiatry·M J DevlinG T Wilson
Jan 3, 2001·The International Journal of Eating Disorders·A WatersG Waller
Apr 3, 2001·Annual Review of Neuroscience·J T WillieM Yanagisawa
Apr 4, 2001·The International Journal of Eating Disorders·J H CrowtherK L Shepherd
May 23, 2001·The Journal of Comparative Neurology·J N MarcusJ K Elmquist
Jul 6, 2001·The International Journal of Eating Disorders·E SticeT Wilson
Feb 13, 2002·The Journal of Clinical Psychiatry·Jose C AppolinarioWalmir Coutinho
Jun 5, 2003·Journal of Psychosomatic Research·Secondo FassinoGiovanni Giacomo Rovera
Aug 6, 2003·The International Journal of Eating Disorders·William P CarterHarrison G Pope
Mar 1, 1959·British Journal of Pharmacology and Chemotherapy·O ARUNLAKSHANA, H O SCHILD
Jul 21, 2004·Bioorganic & Medicinal Chemistry Letters·Laura C McAteeTodd K Jones
Jul 30, 2004·The International Journal of Eating Disorders·Lisa M Yacono Freeman, Karen M Gil
Dec 14, 2004·NeuroImage·Marcia Levin PelchatJ Daniel Ragland
Apr 28, 2005·Nature Neuroscience·Nora D Volkow, Roy A Wise
Aug 16, 2005·Nature·Glenda C HarrisGary Aston-Jones
Dec 17, 2005·Proceedings of the National Academy of Sciences of the United States of America·Benjamin BoutrelLuis de Lecea
Jun 6, 2006·British Journal of Pharmacology·Andrew J LawrenceBrian Oldfield
Jul 4, 2006·Biological Psychiatry·James I HudsonRonald C Kessler
Jul 22, 2006·The Journal of Pharmacology and Experimental Therapeutics·Terry KenakinChristian Watson
Aug 15, 2006·Trends in Neurosciences·Glenda C Harris, Gary Aston-Jones
Jan 30, 2007·Biological Psychiatry·Susan L McElroyUNKNOWN Topiramate Binge Eating Disorder Research Group
Jan 30, 2007·Nature Medicine·Catherine Brisbare-RochFrançois Jenck
Feb 13, 2007·Comprehensive Psychiatry·Richard A GruczaC Robert Cloninger
Feb 15, 2007·Nature Reviews. Neuroscience·Takeshi Sakurai
Jul 10, 2007·Neuroscience and Biobehavioral Reviews·Nicole M AvenaBartley G Hoebel
Oct 12, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Huiyuan ZhengHans-Rudolf Berthoud
Dec 7, 2007·The American Journal of Psychiatry·Denise E WilfleyUNKNOWN Sibutramine Binge Eating Disorder Research Group
Jan 8, 2008·The American Journal of Psychiatry·Joel Yager
Mar 20, 2008·The Journal of Clinical Psychiatry·Kristin N JavarasJames I Hudson
Jul 11, 2008·Neuron·George F Koob

❮ Previous
Next ❯

Citations

Jun 6, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alessandro GozziAngelo Bifone
Aug 13, 2013·International Journal of Endocrinology·Jessica R BarsonSarah F Leibowitz
Sep 1, 2014·Neuroscience and Biobehavioral Reviews·C D'AddarioM Maccarrone
Jan 7, 2016·Current Psychiatry Reports·Shi-Bin LiLuis de Lecea
Nov 27, 2015·Neuropharmacology·Juliane CalvezElena Timofeeva
Mar 8, 2016·Physiology & Behavior·Sara E KeeferGorica D Petrovich
Oct 27, 2015·CNS Spectrums·Chiara Giuliano, Pietro Cottone
Sep 9, 2015·Current Obesity Reports·Jonathan R S Arch
Jul 22, 2014·Medicinal Research Reviews·Quanhui ChenDong Gao
May 2, 2015·Pharmacology, Biochemistry, and Behavior·Manuel Alcaraz-Iborra, Inmaculada Cubero
Jul 19, 2014·Neuropharmacology·Angie M Cason, Gary Aston-Jones
Apr 23, 2013·The International Journal of Neuropsychopharmacology·Robyn Mary BrownAndrew John Lawrence
May 25, 2013·The International Journal of Neuropsychopharmacology·Artur PałaszRyszard Wiaderkiewicz
May 29, 2016·Trends in Neurosciences·Brian A Baldo
May 24, 2016·American Journal of Medical Genetics. Part a·Ann M ManzardoMerlin G Butler
Aug 16, 2016·American Journal of Medical Genetics. Part a·Ann M ManzardoMerlin G Butler
Oct 30, 2016·Pharmacology & Therapeutics·Vidya Narayanaswami, Linda P Dwoskin
Feb 24, 2017·The International Journal of Eating Disorders·Maria Vittoria Micioni Di BonaventuraCarlo Cifani
Nov 22, 2015·Journal of Psychopharmacology·Steven P VickersDavid J Heal
Jan 21, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Catherine F MoorePietro Cottone
Jan 13, 2018·Nutrients·Marta G Novelle, Carlos Diéguez
May 28, 2019·Scientific Reports·Trevor StewardFernando Fernández-Aranda
Jun 5, 2019·Journal of Psychopharmacology·Maria Vittoria Micioni Di BonaventuraCarlo Cifani
Aug 24, 2017·The International Journal of Eating Disorders·Maria Vittoria Micioni Di BonaventuraCarlo Cifani
Mar 25, 2020·Neurotoxicity Research·Mahdi AbounooriMotahareh Rouhi Ardeshiri
May 1, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Adele RomanoSilvana Gaetani
Oct 4, 2018·European Eating Disorders Review : the Journal of the Eating Disorders Association·Marta G Novelle, Carlos Diéguez
Dec 14, 2018·CNS Drugs·Susan L McElroyFrancisco Romo-Nava
Jul 12, 2019·Frontiers in Behavioral Neuroscience·Eric P Zorrilla, George F Koob
Oct 19, 2020·Genes, Brain, and Behavior·Archana Durairaja, Markus Fendt
Jun 5, 2020·The International Journal of Neuropsychopharmacology·Linnea R FreemanGary Aston-Jones
Nov 19, 2020·Nutrients·Emanuela Micioni Di BonaventuraCarlo Cifani
Feb 6, 2021·Journal of Experimental Pharmacology·Michelle N LevitanAntonio E Nardi
Feb 21, 2021·Journal of Neurochemistry·Muthmainah MuthmainahRobyn M Brown

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asprosin

Asprosin is a fasting-induced hormone produced in the white adipose tissue to stimulate the hepatic release of glucose into the bloodstream. Discover the latest research on this protein hormone here.