Role of Organic Anion-Transporting Polypeptides (OATPs) in Cancer Therapy

The AAPS Journal
Nilay ThakkarWooin Lee

Abstract

The superfamily of organic anion-transporting polypeptides (OATPs, gene symbol SLCO) includes important transporters handling a variety of endogenous and xenobiotic substrates. Currently, 11 human OATPs are known and their substrates include endogenous hormones and their conjugates, anticancer drugs, and imaging agents. The contribution of OATPs to the in vivo disposition of these substrates has been extensively investigated. An accumulating body of evidence also indicates that the expression of some OATPs may be up- or downregulated in several types of cancers, suggesting potential pathogenic roles during the development and progression of cancer. Given that the role of OATPs in handling cancer therapeutics has been already covered by several excellent reviews, this review will focus on the recent progresses on the topic, in particular the role of OATPs in the disposition of anticancer drugs, the impact of OATP genetic variations on the function of OATPs, and the OATPs differentially expressed in cancer and their potential roles in cancer development, progression, and treatment.

References

Sep 1, 1996·The Journal of Clinical Investigation·R LuV L Schuster
Jan 25, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·J KönigD Keppler
Apr 26, 2000·The Journal of Biological Chemistry·J KönigD Keppler
Jun 30, 2000·Biochemical and Biophysical Research Communications·I TamaiA Tsuji
Apr 5, 2002·The Journal of Clinical Endocrinology and Metabolism·M V St-PierreT Stallmach
Nov 16, 2002·Prostaglandins & Other Lipid Mediators·Victor L Schuster
Apr 16, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yunhai CuiDietrich Keppler
May 2, 2003·The Journal of Pharmacology and Experimental Therapeutics·Daisuke KobayashiIkumi Tamai
Nov 25, 2003·American Journal of Physiology. Renal Physiology·Hisanobu AdachiTakaaki Abe
Mar 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Tsuyoshi MikkaichiTakaaki Abe
Mar 23, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Gernot ZollnerMichael Trauner
Oct 8, 2005·Cancer Biology & Therapy·Nicola F SmithAlex Sparreboom
May 17, 2006·The Journal of Pharmacology and Experimental Therapeutics·Ilaria BadagnaniKathleen M Giacomini
Aug 10, 2006·The Journal of Pharmacology and Experimental Therapeutics·Antonin LibraLorella Pascolo
Dec 23, 2006·Clinical Pharmacology and Therapeutics·N F SmithA Sparreboom
Jan 12, 2007·Clinical Pharmacology and Therapeutics·H GlaeserR B Kim
Feb 26, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Hong LuCurtis D Klaassen
May 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shuiying HuAlex Sparreboom
Jun 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Akinobu HamadaWilliam D Figg
Jun 17, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Cuiping ChenSonia M de Morais
Aug 1, 2008·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·B Hagenbuch, C Gui
Nov 22, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Evita van de SteegAlfred H Schinkel
Dec 17, 2008·Cancer Research·Wooin LeeWael El-Rifai

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Citations

Jul 28, 2016·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Selvi DurmusAlfred H Schinkel
Oct 27, 2016·Expert Opinion on Drug Metabolism & Toxicology·Daniella KovacsicsCsilla Özvegy-Laczka
Mar 30, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Michael D NyquistElahe A Mostaghel
May 4, 2017·Journal of Pharmaceutical Sciences·Nilay ThakkarKim L R Brouwer
Jun 10, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chuanfen ZhengWeiqun Shu
May 8, 2018·Applied Immunohistochemistry & Molecular Morphology : AIMM·Veronika Buxhofer-AuschTheresia Thalhammer
Nov 18, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Menq-Rong WuJong-Kai Hsiao
Feb 21, 2019·Molecular Pharmacology·Rachael R Schulte, Richard H Ho
Sep 12, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Vanessa MalagninoHenriette E Meyer Zu Schwabedissen
Apr 19, 2020·Journal of Biochemical and Molecular Toxicology·Jiayi WangFanfan Zhou
Aug 19, 2020·The FEBS Journal·Mattia D PizzagalliGiulio Superti-Furga
Jul 5, 2017·Frontiers in Pharmacology·Tea Lanišnik RižnerCsilla Özvegy-Laczka
Jul 18, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shuichi SetoguchiJiro Takata
Jan 30, 2020·Scientific Reports·Siriwalee SiriwiboolAnyanee Kamkaew
Mar 21, 2019·Prostate Cancer and Prostatic Diseases·Mazen AlsinnawiElahe A Mostaghel
Oct 22, 2020·International Journal of Molecular Sciences·Catarina LopesMário Dinis-Ribeiro
Jun 3, 2021·Clinical Science·Sailaja KamarajuSherry-Ann Brown
Jun 22, 2021·ACS Pharmacology & Translational Science·Rachel L Mynott, Craig T Wallington-Beddoe
Jan 8, 2020·Bioconjugate Chemistry·Syed Muhammad UsamaKevin Burgess
Apr 2, 2019·Bioconjugate Chemistry·Syed Muhammad UsamaKevin Burgess
Oct 26, 2018·Bioconjugate Chemistry·Syed Muhammad UsamaKevin Burgess

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