Role of ouabain-like compound in the rostral ventrolateral medulla in rats

The Journal of Clinical Investigation
H TeruyaK Fukiyama

Abstract

To determine whether ouabain-like compound (OLC) exerts modulatory influences on the activity of vasomotor neurons in the rostral ventrolateral medulla (RVLM), we examined the effects of microinjecting ouabain, digoxin-specific antibody Fab fragments, and mAb against ouabain on the rat RVLM. Microinjection of ouabain into the unilateral RVLM of anesthetized normotensive rats elicited dose-dependent increases in mean arterial pressure (MAP) and renal sympathetic nerve activity (RSNA). The pressor and sympathoexcitatory effects of ouabain in the RVLM were reversed by microinjections of an M2 muscarinic antagonist, gallamine, or digoxin-specific antibody Fab fragments. Furthermore, a prior microinjection in the RVLM of gallamine, digoxinspecific antibody Fab fragments, or kainic acid or intravenous injection of hexamethonium all prevented the pressor and sympathoexcitatory effects induced by a subsequent microinjection of ouabain. Microinjections of either digoxinspecific antibody Fab fragments or gallamine per se significantly decreased baseline MAP and RSNA. Injection of digoxin-specific antibody Fab fragments attenuated the effects of a subsequent injection of gallamine. Microinjection of mAb against ouabain, but not nonspecifi...Continue Reading

References

Dec 1, 1991·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·S BalzanS Ghione
Mar 1, 1992·Journal of Neurochemistry·E Satoh, Y Nakazato
Jun 1, 1991·Hypertension·S BovaJ M Hamlyn
Jul 24, 1990·Biochimica Et Biophysica Acta·R DhirR Blostein
Dec 1, 1990·Archives of Biochemistry and Biophysics·J Cuppoletti, A J Abbott
Jul 3, 1990·European Journal of Pharmacology·A D MichelR L Whiting
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·H A Hallaq, G T Haupert
Aug 1, 1987·Canadian Journal of Physiology and Pharmacology·R A DampneyR M McAllen
Sep 13, 1974·Brain Research·J W OlneyO L Ho
Jan 1, 1969·Annual Review of Pharmacology·D R Curtis, J M Crawford
Oct 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·J CurdE Haber
Aug 1, 1994·Kidney International·R G WoolfsonH E de Wardener
Mar 1, 1994·Proceedings of the Society for Experimental Biology and Medicine·P A Doris
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·A A TymiakE Haber
Aug 1, 1993·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·A V KrassioukovL C Weaver

❮ Previous
Next ❯

Citations

Jan 13, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Toshiaki NakagakiKenji Sunagawa
Apr 8, 1998·Current Opinion in Nephrology and Hypertension·A Goto, K Yamada
Mar 24, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Josef ZichaJaroslav Kunes
Dec 24, 2009·Canadian Journal of Physiology and Pharmacology·Katherine V WestcottFrans H H Leenen
Jul 31, 1998·Clinical and Experimental Hypertension : CHE·M P BlausteinV A Golovina
Jun 17, 2009·Fundamental & Clinical Pharmacology·Salvi Tushar RameshV Satya Prasad
Apr 16, 2016·Canadian Journal of Physiology and Pharmacology·Núbia Mantovan FardinRuy R Campos
Mar 17, 2010·Biochimica Et Biophysica Acta·Frans H H Leenen
Sep 12, 2016·Current Hypertension Reports·Rossella IatrinoLaura Zagato
Oct 1, 2011·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A S PadilhaF D M Siman
Jul 28, 2004·Brain Research·Mary-Anne H KentFrans H H Leenen
Feb 26, 2004·The Journal of Pharmacology and Experimental Therapeutics·Mark A PullenRichard M Edwards
Apr 25, 2000·Journal of Cardiovascular Pharmacology·G CargnelliS Bova
Nov 14, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M YamazatoK Fukiyama
Jul 31, 1998·Clinical and Experimental Hypertension : CHE·J W Van Huysse, F H Leenen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.