Role of oxidants/inflammation in declining renal function in chronic kidney disease and normal aging

Kidney International. Supplement
Helen VlassaraGary E Striker

Abstract

Oxidant stress (OS) and inflammation increase in normal aging and in chronic kidney disease (CKD), as observed in human and animal studies. In cross-sectional studies of the US population, these changes are associated with a decrease in renal function, which is exhibited by a significant proportion of the population. However, since many normal adults have intact renal function, and longitudinal studies show that some persons maintain normal renal function with age, the link between OS, inflammation, and renal decline is not clear. In aging mice, greater oxidant intake is associated with increased age-related CKD and mortality, which suggests that interventions that reduce OS and inflammation may be beneficial for older individuals. Both OS and inflammation can be readily lowered in normal subjects and patients with CKD stage 3-4 by a simple dietary modification that lowers intake and results in reduced serum and tissue levels of advanced glycation end products. Diabetic patients, including those with microalbuminuria, have a decreased ability to metabolize and excrete oxidants prior to observable changes in serum creatinine. Thus, OS and inflammation may occur in the diabetic kidney at an early time. We review the evidence that...Continue Reading

References

Sep 19, 1991·The New England Journal of Medicine·Z MakitaH Vlassara
Feb 1, 1985·Journal of the American Geriatrics Society·R Weindruch
Apr 1, 1985·Journal of the American Geriatrics Society·R D LindemanN W Shock
Aug 1, 1995·Journal of the American Society of Nephrology : JASN·J PascualJ Ortuño
Feb 20, 1993·BMJ : British Medical Journal·T G FeestS Hamad
May 15, 1996·JAMA : the Journal of the American Medical Association·E M LevyR I Horwitz
Dec 1, 1995·Journal of the Neurological Sciences·G FazekasG J Krejs
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·T KoschinskyH Vlassara
Jul 1, 1997·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A R SehgalP J Whitehouse
Feb 14, 1998·Kidney International·T MiyataK Kurokawa
Dec 15, 2000·Kidney International·J HimmelfarbE McMenamin
Jan 11, 2001·Blood Purification·J Himmelfarb, E McMonagle
Nov 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Helen VlassaraElliot J Rayfield
Jan 22, 2003·Atherosclerosis·Angelika de BreeDaan Kromhout
Feb 22, 2003·Journal of the American Society of Nephrology : JASN·Jaime UribarriHelen Vlassara
Apr 23, 2003·Journal of the American Society of Nephrology : JASN·Thoralf WendtAnn Marie Schmidt
Jul 9, 2003·Kidney International·Stephen L SeligerCatherine O Stehman-Breen
Dec 20, 2003·American Journal of Nephrology·W Kline BoltonUNKNOWN ACTION I Investigator Group
May 22, 2004·Journal of the American Society of Nephrology : JASN·Andrea LassniggMichael Hiesmayr
Jul 29, 2004·Journal of the American Dietetic Association·Teresia GoldbergHelen Vlassara
Aug 4, 2004·Proceedings of the National Academy of Sciences of the United States of America·Changyong LuHelen Vlassara
Oct 28, 2004·Journal of the American Geriatrics Society·Manjula KurellaKristine Yaffe
May 13, 2005·Journal of the American Society of Nephrology : JASN·Manjula KurellaKristine Yaffe
May 21, 2005·Cellular and Molecular Life Sciences : CMLS·P A Voziyan, B G Hudson
Jan 25, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Alberto Martinez-VeaJesús Angel Oliver
Jul 26, 2006·Neurology·A M MurrayR L Kane
Sep 7, 2006·Proceedings of the National Academy of Sciences of the United States of America·Weijing CaiHelen Vlassara
Oct 7, 2006·The American Journal of Clinical Nutrition·Joachim BleysEliseo Guallar
Jan 9, 2007·The American Journal of Clinical Nutrition·Maret G Traber
Apr 25, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jaime UribarriHelen Vlassara
Nov 8, 2007·JAMA : the Journal of the American Medical Association·Josef CoreshAndrew S Levey
Feb 22, 2008·American Journal of Physiology. Renal Physiology·Roland Schmitt, Lloyd G Cantley
Mar 12, 2008·Drugs & Aging·Ramnath DukkipatiRajnish Mehrotra
May 28, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C M BallantyneJ S Pankow

❮ Previous
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Citations

Dec 3, 2013·Current Diabetes Reports·Helen Vlassara, Jaime Uribarri
Aug 6, 2010·Current Hypertension Reports·Richard J Glassock
Feb 22, 2012·Advances in Therapy·Bruce P Burnett, Robert M Levy
May 26, 2011·Nature Reviews. Endocrinology·Helen Vlassara, Gary E Striker
May 19, 2011·American Journal of Physiology. Endocrinology and Metabolism·Le ZhangJeffrey N Keller
Apr 29, 2011·American Journal of Physiology. Renal Physiology·Pedro A JoseInes Armando
Mar 22, 2013·Acta Medica Croatica : C̆asopis Hravatske Akademije Medicinskih Znanosti·Petar KesBruna Brunetta Gavranić
Nov 6, 2013·International Journal of Hygiene and Environmental Health·Yu-Sheng LinBabasaheb Sonawane
Jan 7, 2014·Experimental Gerontology·Moniek C M de GoeijAnton J M de Craen
Aug 3, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Giovanni TargherChristopher D Byrne
Dec 4, 2014·European Journal of Internal Medicine·Chun-Hung TsengChia-Hung Kao
Feb 27, 2014·Free Radical Research·M PraschbergerH Laggner
Sep 27, 2014·International Journal of Molecular Sciences·Xinhui WangAlan R Parrish
Nov 9, 2011·Clinics in Geriatric Medicine·Charles A Cefalu
Dec 28, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Andreas TomaschitzWinfried März
Dec 24, 2010·Archives of Gerontology and Geriatrics·Delfim DuarteAdelino F Leite-Moreira
Jan 30, 2016·Journal of Diabetes Research·Zihan Zheng, Feng Zheng
Jul 9, 2010·Advances in Chronic Kidney Disease·Jessica R Weinstein, Sharon Anderson
Dec 29, 2015·Advances in Chronic Kidney Disease·Markus Bitzer, Jocelyn Wiggins
Feb 25, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Elani StrejaMoti L Kashyap
Jul 28, 2016·The Veterinary Clinics of North America. Small Animal Practice·Rosanne E Jepson
Dec 30, 2015·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Ivana MikolasevicSandra Milic
Jan 8, 2013·The Medical Clinics of North America·Mark E Williams
Feb 22, 2017·Nature Reviews. Nephrology·Giovanni Targher, Christopher D Byrne
Mar 15, 2013·Blood Purification·Paul LeursPeter Stenvinkel
Aug 5, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Mitsuru OhishiHiromi Rakugi
Apr 28, 2018·Cell Transplantation·Lucia AndradeIrene L Noronha

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