Role of Oxidation-Dependent CaMKII Activation in the Genesis of Abnormal Action Potentials in Atrial Cardiomyocytes: A Simulation Study.

BioMed Research International
Na ZhaoHenggui Zhang

Abstract

Atrial fibrillation is a common cardiac arrhythmia with an increasing incidence rate. Particularly for the aging population, understanding the underlying mechanisms of atrial arrhythmia is important in designing clinical treatment. Recently, experiments have shown that atrial arrhythmia is associated with oxidative stress. In this study, an atrial cell model including oxidative-dependent Ca2+/calmodulin- (CaM-) dependent protein kinase II (CaMKII) activation was developed to explore the intrinsic mechanisms of atrial arrhythmia induced by oxidative stress. The simulation results showed that oxidative stress caused early afterdepolarizations (EADs) of action potentials by altering the dynamics of transmembrane currents and intracellular calcium cycling. Oxidative stress gradually elevated the concentration of calcium ions in the cytoplasm by enhancing the L-type Ca2+ current and sarcoplasmic reticulum (SR) calcium release. Owing to increased intracellular calcium concentration, the inward Na+/Ca2+ exchange current was elevated which slowed down the repolarization of the action potential. Thus, the action potential was prolonged and the L-type Ca2+ current was reactivated, resulting in the genesis of EAD. Furthermore, based on th...Continue Reading

References

Sep 1, 1994·The American Journal of Physiology·W Yuan, D M Bers
Jun 1, 1996·International Journal of Cardiology·A A DawoduP E Puddu
Aug 5, 1998·The American Journal of Physiology·M CourtemancheS Nattel
Dec 30, 1998·Journal of Cardiovascular Electrophysiology·M A Allessie
Jun 11, 1999·The American Journal of Physiology·Y WuM E Anderson
Jan 1, 2000·Cardiovascular Research·R F BoschV Kühlkamp
Dec 13, 2000·Journal of Molecular and Cellular Cardiology·A G Brittsan, E G Kranias
Apr 17, 2002·Journal of the American College of Cardiology·Byung-Soo KimYoung Moo Ro
Jun 14, 2002·Cardiovascular Research·José JalifeMoussa Mansour
Mar 16, 2004·Circulation Research·Xander H T WehrensAndrew R Marks
Jul 28, 2004·Cardiovascular Research·Tong Zhang, Joan Heller Brown
Oct 26, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroshi KatohKunio Shirato
Mar 21, 2006·Journal of the American College of Cardiology·Eugene PattersonSunny S Po
Mar 28, 2006·The Journal of Pharmacology and Experimental Therapeutics·Yejia SongLuiz Belardinelli
Mar 28, 2006·American Journal of Physiology. Heart and Circulatory Physiology·K H W J ten Tusscher, A V Panfilov
Jul 11, 2006·Biochimica Et Biophysica Acta·Dmitry B ZorovSteven J Sollott
Nov 25, 2006·The Journal of Clinical Investigation·Stefan WagnerLars S Maier
Nov 29, 2008·Circulation Research·Lai-Hua XieJames N Weiss
Oct 8, 2009·Circulation. Arrhythmia and Electrophysiology·XiaoYan QiStanley Nattel
Dec 10, 2009·PLoS Computational Biology·Matthew D ChristensenThomas J Hund
May 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Anne BlaichSven Moosmang
Jul 12, 2011·Physiological Reviews·Jeffrey R EricksonMark E Anderson
Jul 26, 2011·The Journal of Clinical Investigation·Paari Dominic SwaminathanMark E Anderson
Sep 17, 2011·Circulation Research·Eleonora GrandiDonald M Bers
Nov 15, 2011·Nature Medicine·B Julie HeMark E Anderson
Jun 9, 2012·Circulation Research·Paari Dominic SwaminathanMark E Anderson
Aug 21, 2012·Antioxidants & Redox Signaling·Stefan WagnerLars S Maier
Sep 27, 2013·Basic Research in Cardiology·Can M SagLars S Maier

❮ Previous
Next ❯

Software Mentioned

SUite of Nonlinear DIfferential ALgebraic Solvers ( SUNDIALS

Related Concepts

Related Feeds

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.