PMID: 9523558Apr 2, 1998Paper

Role of oxidative stress and the glutathione system in loss of dopamine neurons due to impairment of energy metabolism

Journal of Neurochemistry
G D ZeevalkW J Nicklas

Abstract

Alterations in the glutathione system and impairment in energy metabolism have both been implicated in the loss of dopamine neurons in Parkinson's disease. This study examined the importance of cellular glutathione and the involvement of oxidative stress in the loss of mesencephalic dopamine and GABA neurons due to inhibition of energy metabolism with malonate, the reversible, competitive inhibitor of succinate dehydrogenase. Consistent with previous findings, exposure to malonate for 24 h followed by 48 h of recovery caused a dose-dependent loss of the dopamine population with little effect on the GABA population. Toxicity was assessed by simultaneous measurement of the high-affinity uptake of [3H]dopamine and [14C]GABA. Total glutathione content in rat mesencephalic cultures was decreased by 65% with a 24-h pretreatment with 10 microM buthionine sulfoxamine. This reduction in glutathione level greatly potentiated damage to both the dopamine and GABA populations and removed the differential susceptibility between the two populations in response to malonate. These findings point to a role for oxidative stress occurring during energy impairment by malonate. Consistent with this, several spin-trapping agents, alpha-phenyl-tert-bu...Continue Reading

Citations

May 3, 2000·The European Journal of Neuroscience·E RybnikovaM Pelto-Huikko
Sep 28, 2002·The International Journal of Neuroscience·Débora C HipólideJosé N Nobrega
Jul 1, 2020·Cellular and Molecular Neurobiology·Ying TangLi-Hua Zhou
Feb 5, 2005·Journal of Neuroscience Research·Honglei LiuRui-Ming Liu
Apr 23, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Setor K Kunutsor, Jari A Laukkanen
Jan 2, 2003·Nutritional Neuroscience·David Benton
Aug 24, 2005·Antioxidants & Redox Signaling·G D ZeevalkJ Ehrhart
Feb 9, 2017·Cognitive Neurodynamics·Bhagyashree NaikAnuradha Majumdar
Dec 10, 1998·Journal of Biomedical Science·A Y Sun, Y M Chen
Jan 23, 2015·Frontiers in Systems Neuroscience·Shinichi AmanoS Lee Hong
Jul 13, 2004·Annals of the New York Academy of Sciences·Honglei LiuRui-Ming Liu
Dec 13, 2000·Brain Research. Molecular Brain Research·M Romero-RamosA Machado
Sep 10, 2002·Parkinsonism & Related Disorders·Catherine MytilineouJocelyn A Yabut
Feb 9, 2002·Journal of Biochemical and Molecular Toxicology·P G GunasekarG E Isom
Apr 27, 2005·Journal of the Neurological Sciences·Shingo KariyaSatoshi Ueno
Apr 11, 2008·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Gail D ZeevalkLaura P Bernard
Mar 4, 2008·Neuroscience·J C LewersH A Jinnah
Jul 28, 2009·Clinical Neurology and Neurosurgery·Elisabeth AndreadouDemetrios Vassilopoulos

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