Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease.

Free Radical Biology & Medicine
Ze ChenHongliang Li

Abstract

Nonalcoholic fatty liver disease (NAFLD) has emerged as the most common chronic liver disease worldwide and is strongly associated with the presence of oxidative stress. Disturbances in lipid metabolism lead to hepatic lipid accumulation, which affects different reactive oxygen species (ROS) generators, including mitochondria, endoplasmic reticulum, and NADPH oxidase. Mitochondrial function adapts to NAFLD mainly through the downregulation of the electron transport chain (ETC) and the preserved or enhanced capacity of mitochondrial fatty acid oxidation, which stimulates ROS overproduction within different ETC components upstream of cytochrome c oxidase. However, non-ETC sources of ROS, in particular, fatty acid β-oxidation, appear to produce more ROS in hepatic metabolic diseases. Endoplasmic reticulum stress and NADPH oxidase alterations are also associated with NAFLD, but the degree of their contribution to oxidative stress in NAFLD remains unclear. Increased ROS generation induces changes in insulin sensitivity and in the expression and activity of key enzymes involved in lipid metabolism. Moreover, the interaction between redox signaling and innate immune signaling forms a complex network that regulates inflammatory respons...Continue Reading

References

May 1, 1978·Archives of Biochemistry and Biophysics·S S Katyare, J L Howland
Feb 1, 1986·Biochemical Medicine and Metabolic Biology·K S RogersR M Loria
Nov 1, 1986·Proceedings of the Society for Experimental Biology and Medicine·G M Wardlaw, M L Kaplan
Jun 1, 1985·Metabolism: Clinical and Experimental·J TriscariA C Sullivan
Sep 1, 1973·Archives of Biochemistry and Biophysics·H J Forman, I Fridovich
Oct 1, 1980·Archives of Biochemistry and Biophysics·J L Coelho, A E Vercesi
Jul 1, 1996·Physiological Reviews·H F Bunn, R O Poyton
Feb 20, 1999·The Journal of Biological Chemistry·K D ChavinA M Diehl
Aug 24, 1999·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·R K PorterH P Melia
Nov 30, 1999·JAMA : the Journal of the American Medical Association·H Cortez-PintoA M Diehl
Nov 24, 1999·The Journal of Biological Chemistry·R RossignolT Letellier
Aug 30, 2000·Cardiovascular Research·D TomasianJ A Vita
May 22, 2001·Archives of Biochemistry and Biophysics·L Gille, H Nohl
Oct 5, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S Q YangA M Diehl
Jan 26, 2002·Molecular and Cellular Biology·Rachel ZhandeXiao Jian Sun
Feb 6, 2002·Free Radical Biology & Medicine·Stefania PizzimentiGiuseppina Barrera
Nov 26, 2002·Nature·Jiro HirosumiGökhan S Hotamisligil
Jan 24, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zhiping LiAnna Mae Diehl
Feb 26, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Naga ChalasaniDavid W Crabb
May 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·R Michael AnsonMark P Mattson
Oct 24, 2003·The American Journal of Gastroenterology·Luca MieleGiovanni Gasbarrini
Dec 12, 2003·The British Journal of Nutrition·Susanna IossaGiovanna Liverini
Feb 27, 2004·The American Journal of Clinical Nutrition·Charles S LieberLeonore M DeCarli
Mar 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Rafael Radi
Mar 23, 2004·Current Pharmaceutical Design·A Furnkranz, N Leitinger
Jul 3, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Daqing GaoAnna Mae Diehl
Nov 4, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Michal Carmiel-HaggaiNatalia Nieto

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Citations

May 29, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Seonghwan HwangBin Gao
Apr 26, 2020·Antioxidants·Alma MartelliArrigo F G Cicero
Jul 1, 2020·Frontiers in Pharmacology·Yaxing ZhangHongzhi Yang
Oct 9, 2020·Signal Transduction and Targeted Therapy·Huai-Qiang JuRui-Hua Xu
Oct 18, 2020·Antioxidants·Marina Galicia-MorenoJuan Armendariz-Borunda
Oct 21, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Li-Ni SongJin-Kui Yang
Nov 4, 2020·Biomedit︠s︡inskai︠a︡ khimii︠a︡·O N VoloshchukG P Kopylchuk
Nov 29, 2020·Metabolism: Clinical and Experimental·Yanjun GuoChengfu Xu
Jan 17, 2021·International Journal of Environmental Research and Public Health·Seok Hee SeoInhae Kang
Dec 19, 2020·Antioxidants·Erika Ramos-Tovar, Pablo Muriel
Jan 30, 2021·Oxidative Medicine and Cellular Longevity·Krzysztof DrygalskiMateusz Maciejczyk
Dec 29, 2020·Frontiers in Endocrinology·Tim Hendrikx, Christoph J Binder
Dec 30, 2020·Biomolecules·Clémence RivesWalter Wahli
Nov 6, 2020·Oxidative Medicine and Cellular Longevity·Andrea GonzalezClaudio Cabello-Verrugio
Feb 19, 2021·Journal of Gastroenterology and Hepatology·Yu Jung HeoHae Jin Kim
Feb 28, 2021·Complementary Therapies in Medicine·Parivash Shekarchizadeh-EsfahaniCyrus Jalili
Feb 26, 2021·Oxidative Medicine and Cellular Longevity·Fengming XuUta Dahmen
Mar 16, 2021·Frontiers in Medicine·Anna Pia Delli BoviPietro Vajro
Mar 19, 2021·The Journal of Pharmacy and Pharmacology·Ya-Qin YangXing-Xin Yang
Mar 29, 2021·Redox Biology·Maren C Podszun, Jan Frank
Apr 7, 2021·The Journal of Pharmacy and Pharmacology·Shiwangi DwivediAnurag Sharma
Apr 14, 2021·Environmental Science and Pollution Research International·Heba N Gad El-HakHowayda E Khaled
May 1, 2021·International Journal of Molecular Sciences·Hyunmi KimKyoung-Jin Oh

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