PMID: 11922899Mar 30, 2002Paper

Role of P(1) purinergic receptors in myocardial ischemia sensory transduction

Cardiovascular Research
G W ThompsonJ A Armour

Abstract

To characterize the role that cardiac sensory P(1) purinergic (adenosine A(1) or A(2)) receptors play in transducing myocardial ischemia. Porcine nodose ganglion cardiac sensory neuron adenosine A(1) or A(2) receptor function was studied in situ during control states as well as in the presence of the peptides bradykinin and substance P or focal ventricular ischemia. The responses of porcine nodose ganglion cardiac and non-cardiac afferent neuronal somata to adenosine were also studied in vitro. Local application of A(1) or A(2) adenosine receptor agonists modified the activity generated by ventricular sensory neurites associated with 70 and 74% of identified nodose ganglion cardiac afferent somata in situ, respectively, exciting most neurons. In contrast, adenosine reduced the excitability of nodose ganglion cardiac afferent neuronal somata in vitro. Bradykinin and substance P affected 56 and 63%, respectively, of tested afferent neurons. The capacity of ventricular sensory neurites to transduce signals relating to these peptides was virtually eliminated by the presence of P(1) purinergic receptor antagonists. So was their capacity to transduce focal ventricular ischemia. Since most cardiac sensory neurites responded differentl...Continue Reading

Citations

Jun 15, 2013·Pharmacology & Therapeutics·John P HeadrickJason N Peart
Nov 11, 2015·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Avishag Laish-FarkashVladimir Khalameizer
Jul 24, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J Andrew Armour
Mar 2, 2006·Pharmacological Reviews·Geoffrey Burnstock
Aug 2, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Rakesh C AroraJ Andrew Armour

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