PMID: 8943047Nov 26, 1996Paper

Role of p300-family proteins in E1A oncogene induction of cytolytic susceptibility and tumor cell rejection

Proceedings of the National Academy of Sciences of the United States of America
James L CookB A Routes

Abstract

The mechanism by which the adenoviral (Ad) E1A oncogene induces cellular susceptibility to lysis by killer lymphocytes involves interactions between its first exon and different second-exon accessory regions. Mutational analysis showed that two first-exon regions--one in the N terminus and one in the conserved region 1 (CR1) domain--are necessary for this activity. E1A complex formation with cellular p300 protein through these first-exon-encoded regions correlated with induction of the cytolytic susceptible phenotype but was only effective in the context of E1A second-exon expression. An E1A first-exon deletion that prevented p300 binding eliminated both oncoprotein-induced cytolytic susceptibility and rejection of transfected sarcoma cells by immunocompetent animals. These results suggest that the E1A oncogene induces cytolytic susceptibility and tumor rejection by interactions with cellular proteins of the p300 family that affect transcription of genes involved in the cellular response to injury inflicted by host killer cells.

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Citations

Nov 30, 2005·The Journal of Experimental Medicine·John M RoutesLewis L Lanier
Mar 13, 2014·PloS One·Michael J KorrerJohn M Routes
Jul 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·James L CookJay R Radke
Aug 17, 1999·Current Opinion in Immunology·W S WoldA E Tollefson

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