Role of p62 in the regulation of cell death induction

Apoptosis : an International Journal on Programmed Cell Death
Lihong FanHongbo Hu

Abstract

p62 is a multifunctional adaptor protein implicated in various cellular processes. It has been found to regulate selective autophagy, cell survival, cell death, oxidative stress, DNA repair and inflammation, and to play a role in a number of diseases, such as tumourigenesis, Paget's disease of bone, neurodegenerative disease, diabetes, and obesity. Cell death induction is an important cellular process. The dysregulation of cell death induction is involved in the pathogenesis of various diseases, such as cancer, neurodegeneration diseases, and diabetes. In this review, we discuss the functional role of p62 in inducing cell death in response to multiple stimuli, and we summarize the potential signaling pathways that contribute to this regulation. Given the important role of p62 in regulating cell death, p62 is considered to be a reasonable target for managing cell death dysregulation-related pathogenic conditions. A better understanding of the role of p62 and its related mechanisms in regulating cell death is necessary for the more precise utilization of p62 as a target for treating relevant diseases.

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Mar 6, 2019·Phytotherapy Research : PTR·Yu-Hsin TsengPei-Chin Lin
Mar 13, 2019·The Journal of Pathology. Clinical Research·Suzan SchwertheimHideo A Baba
Jun 25, 2020·Cells·Anna Martina BattagliaFlavia Biamonte
Aug 29, 2018·Aging·Nataliya G KolosovaAlexander M Shneider
Sep 13, 2020·Molecular and Cellular Biochemistry·Huan YuanJian-Hui Xiao
Oct 4, 2018·Der Pathologe·S Berezowska

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Methods Mentioned

BETA
ubiquitination
nuclear translocation
protein

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