Role of paediatric assist device in bridge to transplant

Annals of Cardiothoracic Surgery
R HetzerEva Maria Delmo Walter

Abstract

While heart transplantation has gained recognition as the gold standard therapy for advanced heart failure, the scarcity of donor organs has become an important concern. The evolution of surgical alternatives such as ventricular assist devices (VADs), allow for recovery of the myocardium and ensure patient survival until heart transplantation becomes possible. This report elaborates the role of VADs as a bridge to heart transplantation in infants and children (≤18 years old) with end-stage heart failure. A retrospective review of the medical records of 201 heart transplant recipients between May 1986 and September 2014 identified 78 children [38.8%; mean age 7.2 (7.8±6.0) years old; IQR: 2.6-11.8 years] with advanced heart failure who were supported with a VAD [left VAD (LVAD) =21; biventricular VAD (BVAD) =57] as a bridge to heart transplantation. Fourteen (17.9%) patients were less than 1 year old; 15 (19.2%) children had a cardiac arrest and underwent cardiopulmonary resuscitation, with 7 of these patients also requiring extracorporeal membrane oxygenation (ECMO) support prior to implantation of a VAD. The aetiology of heart failure was primarily cardiomyopathy (dilative, restrictive from endocardial fibrosis, idiopathic or ...Continue Reading

Citations

Aug 4, 2018·The International Journal of Artificial Organs·Damian ObidowskiKrzysztof Jóźwik
Jul 27, 2017·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Christopher E MascioJonathan J Rome
Nov 30, 2019·Expert Review of Medical Devices·Roland HetzerEva Maria Javier Delmo
Oct 19, 2019·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Inderjeet BhatiaWing-Kuk Timmy Au
Apr 8, 2020·Critical Care : the Official Journal of the Critical Care Forum·Shannon M FernandoKwadwo Kyeremanteng
Jun 1, 2021·Interactive Cardiovascular and Thoracic Surgery·Johanna SchleinDaniel Zimpfer
May 17, 2021·Journal of Molecular and Cellular Cardiology·Shi ShenStuart G Campbell

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