Role of paliperidone palmitate 3-monthly in the management of schizophrenia: insights from clinical practice

Neuropsychiatric Disease and Treatment
Alicia Lopez, Jose Rey

Abstract

Schizophrenia is a complex, chronic psychiatric disorder associated with reduced quality of life and shortened life span. The majority of patients with schizophrenia will relapse within 1 year following an acute episode. The ultimate goals of treatment are to improve functional capabilities, minimize residual symptoms during periods of remission, and decrease relapse frequency and duration, as each relapse brings with it the possibility of a worsening prognosis. Maintaining therapeutic continuity is essential for long-term, positive patient outcomes in schizophrenia. Medication nonadherence and symptomatic relapses magnify the disease burden associated with this disorder. Medication adherence in chronic disease states generally improves with a decrease in dosing frequency. Long-acting injectable (LAI) antipsychotics were developed to improve patient outcomes secondarily to improving medication adherence. Paliperidone palmitate 3-monthly injection (PP3M) is the only LAI available with a quarterly dosing interval. PP3M has been US Food and Drug Administration-approved for use in the long-term maintenance treatment of schizophrenia in patients already controlled on once-monthly PP LAI (paliperidone palmitate once-monthly injection...Continue Reading

Citations

Nov 30, 2019·The Psychiatric Quarterly·Mary V Seeman

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Methods Mentioned

BETA
pharmacotherapy
SGA

Clinical Trials Mentioned

NCT02146547
NCT02431702
NCT03345342

Software Mentioned

EULAST

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